Structure and Intrinsic Disorder in Enzymology

Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study Features chapter contributions from international leaders in the field INDICE: 1. Enzymology: Early insights 2. Decoding the twin magics of fast rates and specificity 3. Protein flexibility and cryo-enzymology: The trade-off between stability and catalytic rates 4. Structure and Disorder: Functions depend upon this new binary 5. Hierarchies of intrinsic disorder 6. Methods for measurement of disorder in proteins 7. Bioinformatics tools for predictions of structure, disorder, and function 8. How do new enzyme activities evolve? 9. Emerging role of Intrinsic disorder in biocatalysis 10. Role of disorder in protein promiscuity 11. Role of disorder in protein moonlighting 12. Molten globular enzymes 13. Intrinsic disorder and allosteric regulation 14. Protein crowding: How it affects structure, disorder and catalysis 15. How structure and disorder affect each other? 16. Role of disorder in post-translational modifications 17. Structure, Intrinsic disorder and protein misfolding/aggregation 18. Intrinsic disorder, amyloids and prion-like domains in proteins 19. IDPRs of membrane proteins influence membrane curvature 20. How binding to surfaces affects disorder? 21. Intrinsic disorder, phase separation and membrane-less cellular organelles

• ISBN: 978-0-323-99533-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 408
• Fecha Publicación: 01/10/2022
• Nº Volúmenes: 1
• Idioma: Inglés