Phosphines as Reagents and Catalysts in Organic Synthesis

Phosphines as Reagents and Catalysts in Organic Synthesis provides comprehensive coverage of metal-free organic reactions with phosphines as reagents or catalysts, as well as their synthetic uses. The work begins with a historical overview of the use of phosphines in metal-free organic reactions, followed by details of their physical properties and the source and preparation methods for representative phosphines and chiral variants. The applications of phosphines as reagents and catalysts in organic synthesis are discussed, along with case studies organized according to reaction type. Researchers, graduate students and undergraduates working in organic synthesis will find this work an invaluable resource. These reactions include halogenation under Appel conditions, Wittig reaction, Staudinger reaction, Mitsunobu reaction, alcohol acylation and kinetic resolution, Rauhut-Currier reaction, Morita-Baylis-Hillman reaction, conjugate addition, umpolung additions, annulation reactions, allylic substitution, allylic amination, and isomerization reactions. For each reaction an overview of the state-of-the-art is presented along with the reaction data, enantioselective version using chiral phosphine, and its application in the synthesis of biologically active compounds and total synthesis of natural products. The work concludes with a summary that highlights the most promising reactions for future development in this field of research. Covers the application of organic reactions involving phosphine as reagents and catalysts in organic synthesis and biological chemistryFeatures synthetic methods for creating heterocyclic compoundsIncludes comprehensive coverage of organic reactions and reaction mechanisms involving phosphine as reagents and catalysts INDICE: 1. Introduction 2. Lewis basicity of phosphines 3. Halogenation and related reactions under Appel conditions 4. Wittig reactions 5. Staudinger reactions 6. Mitsunobu reactions 7. Alcohol acylation and kinetic resolution 8. Rauhut-Currier reactions 9. Morita-Baylis-Hillman reactions 10. Conjugate additions 11. Umpolung additions 12. Annulation reactions 13. Allylic substitution and allylic amination 14. Isomerization 15. Aldol and nitroaldol reaction 16. Ring-opening reaction of epoxides and aziridines 17. Diels-Alder Reactions 18. Miscellaneous reactions 19. Concluding remarks 20. Abbreviations 21. Acknowledgment

• ISBN: 978-0-12-814786-3
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/01/2019
• Nº Volúmenes: 1
• Idioma: Inglés