Tropomyosin is one of the two core components of the actin filament and is involved in regulating most if not all functions of these filaments. Tropomyosinhas brought together research leaders in this field to review not only what we know but also what the future holds for this field of research. All aspects of tropomyosin biology are covered from gene structure and expression to protein structure, their role in cell function and disease and finally to mechanisms of their function. The book is essential reading for anyone interested in cell structure and function. The actin architectural system is involved in the majority of cellular processes and this book explains how the tropomyosins contribute to this diversity of function. It is not only a comprehensive resource for those working in the field but is also designed to introduce the broader research community to these important molecules. INDICE: From the contents Introduction and Historical Perspective.- Structure and Evolution of Tropomyosin Genes.- Tropomyosin Exons as Models for Alternative Splicing.- Tropomyosin Gene Expression in Vivo and in Vitro.- Tropomyosin: Function Follows Structure.- Dimerization of Tropomyosins.- Cooperative Binding of Tropomyosin to Actin.- Tropomyosin and the Steric Mechanism of MuscleRegulation.- Role of Tropomyosin in the Regulation of Contraction in Smooth Muscle.- Tropomyosin as a Regulator of Cancer Cell Transformation.- The Role ofTropomyosin in Heart Disease.- Tropomyosins in Skeletal Muscle Diseases.- Tropomyosins in Human Diseases: Ulcerative Colitis.- Tropomyosin Function in Yeast.- Isoform Sorting of Tropomyosins.- Human Tropomyosin Isoforms in the Regulation of Cytoskeleton Functions.- Tropomyosins Regulate the Impact of Actin Binding Proteins on Actin Filaments.- Tropomyosin and ADF/cofilin as collaborators and competitors.- Caldesmon and the Regulation of Cytoskeletal Functions.
- ISBN: 978-0-387-85765-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 325
- Fecha Publicación: 01/12/2008
- Nº Volúmenes: 1
- Idioma: Inglés