Addressing a cutting–edge, multidisciplinary field, this book reviews nanomaterials and their biomedical applications. It covers regeneration, implants, adhesives, and biosensors and strategies for more efficient therapy, diagnosis, and drug delivery with the use of nanotechnology. Addresses the increasing demand for nanomedicine in a cutting–edge, multidisciplinary field Introduces concepts, strategies, and requirements of developing materials Discusses hot topics in drug delivery, such as neural regeneration, cartilage regeneration, bone tissue regeneration, dental regeneration, biomedical imaging, tissue adhesives and biosensors Includes a chapter about nanotoxicology to help readers further understand the biocompatability of nanomaterials INDICE: List of Contributors xi .Preface xiii .1 Nanomaterials for Medicine 1Mustafa O. Guler and Ayse B. Tekinay .1.1 Introduction, 1 .1.2 Nanoscale Material Properties, 2 .1.3 Nanomaterials for Understanding Disease Pathways, 2 .1.4 Nanomaterials for Therapy, 3 .1.5 Challenges and Future Prospects, 5 .2 Nanosized Delivery Systems for Tissue Regeneration 7Goksu Cinar, Didem Mumcuoglu, Ayse B. Tekinay, and Mustafa O. Guler .2.1 Introduction, 7 .2.2 Delivery of Protein Therapeutics with Nanocarriers for Tissue Regeneration, 10 .2.2.1 GFs and Cytokines, 10 .2.3 Gene and siRNA Delivery with Nanocarriers for Tissue Regeneration, 13 .2.3.1 Gene Delivery, 13 .2.3.2 siRNA Delivery, 15 .2.4 Systemic Targeting and Cellular Internalization Strategies for Tissue Regeneration, 15 .2.4.1 Targeted Delivery, 15 .2.4.2 Cellular Internalization Strategies, 18 .2.5 Future Perspectives, 20 .References, 22 .3 Nanomaterials for Neural Regeneration 33Melike Sever, Busra Mammadov, Mevhibe Gecer, Mustafa O. Guler, and Ayse B. Tekinay .3.1 Introduction, 33 .3.1.1 Extracellular Matrix of Central Nervous System, 33 .3.1.2 ECM of Peripheral Nervous System, 37 .3.1.3 Urgent Need for Materials to Induce Regeneration in Nervous Tissue, 39 .3.2 Nanomaterials for Neural Regeneration, 40 .3.2.1 Physical Functionalization of Nanomaterials to Induce Neural Differentiation, 40 .3.2.2 Effects of Mechanical Stiffness on Cellular Behavior, 40 .3.2.3 Effects of Dimensionality on Cellular Behavior, 42 .3.2.4 Effects of Substrate Topography on Cell Behavior, 43 .3.2.5 Effects of Electrical Conductivity on Cell Behavior, 44 .3.3 Chemical and Biological Functionalization of Nanomaterials for Neural Differentiation, 45 .3.3.1 Effects of Biologically Active Molecules on Cell Behavior, 45 .3.3.2 Effects of Chemical Groups on Cellular Behavior, 46 .3.3.3 Effects of Biofunctionalization on Cellular Behavior Through ECM Derived Short Peptides, 48 .3.4 Conclusion, 50 .References, 51 .4 Therapeutic Nanomaterials for Cartilage Regeneration 59Elif Arslan, Seher Ustun Yaylac , Mustafa O. Guler, and Ayse B. Tekinay .4.1 Introduction, 59 .4.2 Current Treatment Methods for Cartilage Injuries, 63 .4.3 Tissue Engineering Efforts, 66 .4.3.1 Natural Polymers, 67 .4.3.2 Synthetic Polymers, 69 .4.3.3 Composite Materials, 70 .4.3.4 Physical Stimuli, 71 .4.4 Clinical Therapeutics for Cartilage Regeneration, 72 .4.5 Conclusions and Future Perspectives, 73 .References, 78 .5 Wound Healing Applications of Nanomaterials 87Berna Senturk, Gozde Uzunalli, Rashad Mammadov, Mustafa O. Guler, and Ayse B. Tekinay .5.1 Introduction, 87 .5.1.1 The Structure of Healthy Mammalian Skin, 88 .5.1.2 The Mechanisms of Wound Healing, 89 .5.1.3 Repair Process in Chronic Wounds, 94 .5.2 Applications of Nanomaterials for the Enhancement of Wound Healing Process, 95 .5.2.1 Artificial Skin, 96 .5.2.2 Natural Nanomaterials for Wound Healing, 97 .5.2.3 Synthetic Nanomaterials for Wound Healing, 100 .5.2.4 Wound Dressings Containing Growth Factors, 101 .5.2.5 Biomimetic Materials, 102 .5.2.6 Current Challenges in the Design of Nanomaterials for Chronic Wound Management, 103 .5.3 Peptide Nanofiber Gels for Wound Healing, 105 .5.3.1 Relevance of Nanofibrous Structure of Peptide Gels for Wound Healing, 106 .5.3.2 Engineered PA Nanofiber Gels for Wound Healing and Insights into Various Designs, 107 .References, 110 .6 Nanomaterials for Bone Tissue Regeneration and Orthopedic Implants 119Gulcihan Gulseren, Melis Goktas, Hakan Ceylan, Ayse B. Tekinay, and Mustafa O. Guler .6.1 Introduction, 119 .6.2 Bone Matrix, 120 .6.2.1 Organic Matrix and Bioactivity, 120 .6.3 Inorganic Matrix, Mineralization, and Bone Organization, 122 .6.3.1 Mechanical Properties and Structural Hierarchy of Bone Tissue, 123 .6.4 Regulation of Bone Matrix in Adult Tissue, 125 .6.4.1 Angiogenic Factors in Bone Remodeling, 126 .6.5 Strategies for Bone Tissue Regeneration, 127 .6.5.1 Hard Grafts for Bone Regeneration, 127 .6.6 Soft Grafts for Bone Regeneration, 131 .6.6.1 Peptide Based Bone Grafts, 132 .6.6.2 Polymer Nanocomposites as Bone Grafts, 134 .6.7 Future Perspectives, 138 .References, 138 .7 Nanomaterials for the Repair and Regeneration of Dental Tissues 153Gulistan Tans k, Alper Devrim Ozkan, Mustafa O. Guler, and Ayse B. Tekinay .7.1 Introduction, 153 .7.2 Formation of Dental and Osseous Tissues, 155 .7.3 Dental Implants, 156 .7.3.1 Metallic Implants, 158 .7.3.2 Ceramic Implants, 158 .7.3.3 Polymeric Implants, 159 .7.4 Osseointegration of Dental Implants, 159 .7.5 Uses of Nanotechnology in the Development of Dental Implants, 160 .7.5.1 Enhancement of the Osseointegration Process, 161 .7.5.2 Pulp and Dentin Tissue Regeneration, 162 .7.5.3 Whole Tooth Regeneration, 165 .7.6 Conclusions and Future Perspectives, 166 .References, 166 .8 Nanomaterials as Tissue Adhesives 173I. Ceren Yasa, Hakan Ceylan, Ayse B. Tekinay, and Mustafa O. Guler .8.1 Introduction, 173 .8.2 Tissue Adhesives Based on Synthetic Polymers, 176 .8.3 Naturally Derived Tissue Adhesives, 180 .8.4 Bioinspired Strategies, 182 .8.5 Nanoenabled Adhesives, 186 .8.6 Conclusion and Future Prospects, 186 .References, 189 .9 Advances in Nanoparticle Based Medical Diagnostic and Therapeutic Techniques 197Melis Sardan, Alper Devrim Ozkan, Aygul Zengin, Ayse B. Tekinay, and Mustafa O. Guler .9.1 Introduction, 197 .9.2 NPs used in MRI, 200 .9.2.1 T1 CAs, 201 .9.2.2 T2 CAs, 205 .9.2.3 Dual Modal Contrast Agents, 207 .9.3 NPs used in Computed Tomography, 208 .9.3.1 Noble Metal Based NPs, 209 .9.3.2 Heavy Metal Based NPs, 211 .9.4 NPs used in Optical and Fluorescence Imaging, 213 .9.4.1 Quantum Dots, 214 .9.4.2 AuNPs, 216 .9.4.3 UCNPs, 217 .9.5 Theranostic Approaches and Multimodal Systems, 218 .9.6 Overlook and Future Directions, 222 .References, 223 .10 Biosensors for Early Disease Diagnosis 235Ahmet E. Topal, Alper Devrim Ozkan, Aykutlu Dana, Ayse B. Tekinay, and Mustafa O. Guler .10.1 Introduction, 235 .10.2 Biosensor Elements, 237 .10.2.1 Recognition Elements, 237 .10.2.2 Output Type and Detection Techniques, 239 .10.2.3 Optical Biosensors, 248 .10.2.4 Electrical and Electrochemical Biosensors, 250 .10.2.5 Mechanical Biosensors, 251 .10.2.6 Other Biosensor Types, 252 .10.3 The Impact of Nanotechnology and Nanomaterials in Biosensor Design, 253 .10.4 Early Diagnosis and Biosensor Based Disease Detection, 255 .10.5 Conclusion and Future Directions, 258 .References, 259 .11 Safety of Nanomaterials 271Nuray Gunduz, Elif Arslan, Mustafa O. Guler, and Ayse B. Tekinay .11.1 Introduction, 271 .11.2 Characterization, Design, and Synthesis of Nanomaterials, 272 .11.2.1 Chemical Identity and Physicochemical Properties, 272 .11.2.2 Biological Identity, 275 .11.3 Interactions at the Cell Material Interface, 277 .11.3.1 Intracellular Activity, 278 .11.3.2 Cellular Uptake Mechanisms, 283 .11.4 Assays for Cell Viability/Proliferation, 283 .11.4.1 Assays for Oxidative Stress and Apoptosis Mechanisms, 284 .11.4.2 Evaluation of Uptake and Accumulation of ENMs, 284 .11.4.3 Genotoxicity Assays, 285 .11.5 Animal Models and Long Term Risk Assessment, 286 .11.5.1 The Blood Brain Barrier, 286 .11.6 Conclusions and Future Perspectives, 290 .References, 291 .Index 299
- ISBN: 978-1-118-98745-2
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 328
- Fecha Publicación: 01/04/2016
- Nº Volúmenes: 1
- Idioma: Inglés