INDICE: Chapter 1. Introduction: Gene discovery from positional cloning to genomic cloning. Chapter 2. High throughput gene expression analysis and the identification of expression QTLs. Chapter 3. DNA methylation in the pathogenesis of autoimmunity. Chapter 4. Ccell-based analysis with microfluidic chip. Chapter 5. Missing Dimension: protein turnover rate measurement in gene discovery. Chapter 6. Bioinformatics tools for the prediction of gene function. Chapter 7. Determination of Genomic locations of targeted genetic loci. Chapter 8. Mutation discovery using high throughput mutation screening technology. Chapter9. Candidate screening through gene expression profile. Chapter 10. Candidatescreening through high-density SNP array. Chapter 11. Gene discovery through direct genome sequencing. Chapter 12. Candidate screening through bioinformatics tools. Chapter 13. Using an integrative strategy to identify mutations. Chapter 14. Determination of the function of a mutant in a gene. Chapter 15. Confirmation of a mutation by multiple molecular approaches. Chapter 16. Confirmation of a mutation by microRNA. Chapter 17. Confirmation of function of a gene by translational approaches. Chapter 18. Confirmation of single nucleotide mutations. Chapter 19. Initial identification and confirmation of a QTL gene. Chapter 20. Gene discovery of crop diseases in the post genome era. Chapter 21. Impact of whole genome genetic element analysis on gene discovery of disease models. Chapter 22. Impact of whole genome protein analysis on gene discovery ofdisease models.
- ISBN: 978-0-470-49946-7
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 624
- Fecha Publicación: 18/03/2011
- Nº Volúmenes: 1
- Idioma: Inglés