This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field INDICE: Structure of the Proteasome Tobias Jung and Tilman Grune Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components Niki Chondrogianni and Efstathios S. Gonos Immunoproteasomes: Structure, Function, and Antigen Presentation Deborah A. Ferrington and Dale S. Gregerson Interactions of the Proteasomal System with Chaperones - Protein Triage and Protein Quality Control Marc Kästle and Tilman Grune Proteasome Inhibitors Boris Cvek Degradation of Damaged Proteins - The Main Function of the 20S Proteasome Andrew. M. Pickering and Kelvin. J. A. Davies Changes of the Proteasomal System During the Aging Process Martin A. Baraibar and Bertrand Friguet Proteasome and Cancer Betul Catalgol The Ubiquitin Proteasome System and Cardiovascular Disease. Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases Fu Shang and Allen Taylor Proteasome and Neurodegenerative Diseases Betul Catalgol and Tilman Grune
- ISBN: 978-0-12-397863-9
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 436
- Fecha Publicación: 07/08/2012
- Nº Volúmenes: 1
- Idioma: Inglés