Interest in the humane and scientifically justifiable use of research animalshas intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovasculareffects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms. The first two editions of this standard reference text have been cited well over 150 times, according to SCI An expanded first chapter will include more information on the cardiovascular effects of post-operative analgesia Will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice INDICE: General principles of animal selection and normal physiological values.- Anesthesia, chemical restraint (sedation), and analgesia.- Normal cardiovascular parameters.- Measuring cardiac function.- Measuring vascular function and ventricular/arterial coupling dynamics.- Isolated heart preparations, problems and pitfalls.- Cardiovascular effects anesthetics, sedatives and post-operative analgesic agents.- Iatrogenic and naturally occurring animal models of valvular, infectious and arrhythmic cardiovascular disease.- Iatrogenic models of ischemic heart disease.- Iatrogenic, transgenic and naturally occurring models of cardiomyopathy and heart failure.- Iatrogenic and transgenic models of hypertension.- Iatrogenic and transgenic models of atherosclerotic disease.- Animal models for the study of neurohumeral and central neural control of the cardiovascular system.- Cardiovascular studies involving other specific genetic knockouts.
- ISBN: 978-0-387-95961-0
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 330
- Fecha Publicación: 01/06/2009
- Nº Volúmenes: 1
- Idioma: Inglés