The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

This book presents advances in the field of neuronal mitochondria functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.     Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death     Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments     Includes examples of mitochondrial drugs, development, and mitochondria–targeted approaches for more efficient treatment methods and further developments in the field     Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders INDICE: Section I: Mitochondrial Structure and Ion ChannelsChapter 1: Mitochondrial Permeability Transition: Look from a Different AngleN. Brustovetsky .Chapter 2: The mitochondrial permeability transition pore, the c–subunit of the F1FO ATP synthase, cellular development and synaptic efficiencyE.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian .Chapter 3: Mitochondrial channels in neurodegenerationP.M. Peixoto, K.W. Kinnally and Evgeny PavlovChapter 4: Mitochondrial Ca2+ Transport in the Control of Neuronal Functions: Molecular and Cellular MechanismsY.M. UsachevSection II: Control of Mitochondrial Signaling NetworksChapter 5: AMP–activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for NeuroprotectionP. Weisova, S. Pfeiffer and J.H.M. PrehnChapter 6: HDAC6: a molecule with multiple functions in neurodegenerative diseasesY. Yan and R. JiaoChapter 7: Neuronal Mitochondrial TransportA.L. Knight, Y. Chen, T. Sun and Z.H. ShengChapter 8: Mitochondria in Control of Hypothalamic Metabolic CircuitsC.M. Nasrallah and T.L. HorvathChapter 9: Mitochondria Anchored at the SynapseG.A. Spirou, D. Jackson and G.A. PerkinsSection III: Defective Mitochondrial Dynamics and MitophagyChapter 10: Neuronal mitochondria are different: relevance to neurodegenerative diseaseS.B. Berman and J.M. HardwickChapter 11: PINK1 as a Sensor for Mitochondrial Function: Dual RolesE.K. Steer, M.K. Dail and C.T. ChuChapter 12: A get–together to tear it apart: the mitochondrion meets the cellular turnover machineryG.L. McLelland and E.A. FonChapter 13: Mitochondrial involvement in neurodegenerative dementiaL. Bonanni, V. Frazzini, A. Thomas and M. OnofrjSection IV: Mitochondria–Targeted Therapeutics and Model SystemsChapter 14: Neuronal Mitochondria as a Target for the Discovery and Development of New TherapeuticsV.K. GribkoffChapter 15: Mitochondria as a Therapeutic Target for Alzheimer s diseaseC.H.L. Hung, S.S.Y. Chung, S.M.Y. Lee and R.C.C. ChangChapter 16: Mitochondria in Parkinson DiseaseG. Arena and E.M. ValenteChapter 17: Therapeutic Targeting of Neuronal Mitochondria in Brain InjuryH.M. Yonutas, E.D. Hall and P.G. SullivanChapter 18: The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapiesD. Soiferman and A. Saada

• ISBN: 978-1-118-70923-8
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 448
• Fecha Publicación: 01/12/2015
• Nº Volúmenes: 1
• Idioma: Inglés