Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered. Profiles paraneoplastic diseases by tumor typeIdentifies the pathogenetic mechanisms of PNS and provides epidemiological analysisPresents individual syndromes of the CNS, PNS, NMJ, and muscleInvestigates the role of antibody markersDifferentiates cytoplasmic, nuclear, and neuronal cell surface reactivitiesDiscusses immune-oncological drugs causing diseases that are indistinguishable from PNSReviews therapeutic strategies and clinical approach to PNS patients INDICE: Section I. Introduction and Overview1. Introduction and overview of immunopathological mechanisms and future directions2. Changing landscape in the field of paraneoplastic neurology: Personal Perspectives over a 35-year career3. Pathogenesis and immunopathology of paraneoplastic disordersSection II. Paraneoplastic neurological syndromes4. Epidemiology of paraneoplastic neurologic syndromes5. Clinical approach to diagnosis of paraneoplastic neurological syndromes6. Overview of treatment strategies in paraneoplastic neurological syndromes7. Methods to Detect Paraneoplastic Antibodies8. Paraneoplastic encephalitis9. Autoimmune and paraneoplastic seizures 10. Paraneoplastic Cerebellar and Brainstem Disorders11. Paraneoplastic/autoimmune myelopathies12. Paraneoplastic vision loss13. Paraneoplastic movement disorders14. Movement disorders associated with pediatric encephalitis15. Paraneoplastic neuropathies and peripheral nerve hyperexcitability disorders16. Paraneoplastic autonomic neuropathies and GI dysmotility 17. Myasthenia Gravis - Pathophysiology, diagnosis and treatment18. Lambert-Eaton myasthenic syndrome19. Paraneoplastic myopathiesSection III. Paraneoplastic autoantibodies20. Intracellular paraneoplastic autoantibodies21. Antibodies to neural cell surface and synaptic proteins in paraneoplastic neurologic syndromes22. Optimizing the diagnostic performance of neural antibody testing for paraneoplastic and autoimmune encephalitis in clinical practiceSection IV. Paraneoplastic neurological and autoantibody accompaniments of cancer23. Paraneoplastic Autoimmune Neurological Disorders associated with Thymoma24. Paraneoplastic Neurologic Manifestations of Neuroendocrine tumors25. Paraneoplastic Neurological Syndrome associated with Gynaecological and Breast malignancies26. Hematological malignancies and hematopoietic stem cell transplantation27. Paraneoplastic neurological syndrome and autoantibody accompaniments of germ cell tumorsSection V. Neurological complications of cancer immunotherapy28. Neurological manifestations of autoimmunity with immune checkpoint inhibitors
- ISBN: 978-0-12-823912-4
- Editorial: Elsevier
- Encuadernacion: Cartoné
- Páginas: 496
- Fecha Publicación: 25/04/2024
- Nº Volúmenes: 1
- Idioma: Inglés