Retinoic Acids in Cancer therapy: Mechanisms of sensitivity, resistance, and methods of delivery

Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides a comprehensive overview on how ATRA (All Trans Retinoic Acid) kills cancer cells and how some cells survive when they are treated with this drug. With a strong focus on cell pathways and compartments involved in the action of RAs in inhibiting cell proliferation in various cancers, coverage includes how aggressive tumors develop as well as several escape routes conferring RAs-resistance. In 16 chapters the book describes the molecular structure and biological properties of ATRA, explains the mechanisms of resistance to ATRA, defines the efficiency of trans-retinoic acid on 7 various cancers, shows strategies to improve ATRA cancer treatment and provides future perspectives in ATRA applications. This book is a valuable reference for health professionals, scientists, researchers, health practitioners, students, and all those who wish to broaden their knowledge in the field to develop new drugs or treatment strategies that improve the therapeutic efficacy of ATRA in cancers. Identifies the most important pathways including in apoptosis (intrinsic, extrinsic) in an informative and concise schematic wayProvides new perspectives on understanding the impact of autophagy in RAs induced apoptosis and how targeting autophagy could improve RAs induced apoptosis in different cancersDiscusses strategies to change the fate of cancer stem cells and target them with RAs to improve their effectiveness INDICE: 1. Molecular structure and biological properties of ATRA2. Cellular and molecular determinants of all-trans retinoic acid sensitivity in different cancers3. Mechanisms of resistance to ATRA4. Efficiency of All-Trans Retinoic Acid on Gastric Cancer5. Efficiency of All-Trans Retinoic Acid on glioblastoma6. Efficiency of All-Trans Retinoic Acid on lung cancer7. Efficiency of All-Trans Retinoic Acid on breast cancer8. Efficiency of All-Trans Retinoic Acid on liver cancer9. Efficiency of All-Trans Retinoic Acid on stomach cancer10. Efficiency of All-Trans Retinoic Acid on colon cancer11. Bioengineered models for investigating ATRA anticancer efficacy and biocompatibility12. Delivery methods for ATRA13. Apoptosis, autophagy, and UPR and its impact in ATRA-induced toxicity in cancer cells.14. ATRA and Cancer Stem Cell Biology15. OMICs strategies to Improve the ATRA Cancer Treatment16. Future Perspectives in ATRA applications in Cancer Biology and Nano technology

• ISBN: 978-0-443-22305-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 216
• Fecha Publicación: 01/02/2025
• Nº Volúmenes: 1
• Idioma: Inglés