The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and increased investigation into the neurobiological basis of behavior using zebrafish. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, and conveniently small size and transparent embryology. Behavioral and Neural Genetics of Zebrafish assembles state of the art methodologies and the most current concepts pertinent to the neurobehavioral genetics of zebrafish. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and big-data related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics fieldDescribes description of behavioral, genetic, and neural methods and concepts and adult and larval zebrafishFeatures examples of zebrafish models of human central nervous system disordersDiscusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics INDICE: Section I. Introduction to Zebrafish: Natural Habitat, Ethology, and Appropriate Maintenance Conditions 1. The biotic and abiotic environment of zebrafish 2. Maintenance and breeding of zebrafish, with some ethological and ecological considerations in mind Section II. The Behavior of the Fry 3. The larval visual system and behavioral responses to visual stimuli 4. Visual escape in larval zebrafish: Stimuli, circuits, and behavior 5. Functional review of hearing in zebrafish 6. The development of social behavior 7. Classical and operant conditioning in larval zebrafish Section III. The Behavior of the Adult 8. Motor patterns and swim path characteristics: the ethogram of zebrafish 9. Behavioral criteria and techniques to define sleep in zebrafish 10. Fear responses and antipredatory behavior of zebrafish: A translational perspective 11. Social behavior and its psychopharmacological and genetic analysis in zebrafish 12. Associative and non-associative learning in adult zebrafish 13. Relational learning in zebrafish: A model of declarative memory in humans? Section IV. Genetic Methods for Zebrafish 14. Molecular genetic approaches to dissect complex behaviors in zebrafish 15. Behavioural research in zebrafish (Danio rerio): strain as source of variation 16. Designer mutants for behavioral genetics 17. Optogenetics 18. The CRISPR/Cas system in zebrafish 19. PhOTO Zebrafish and primed conversion: Advancing the mechanistic view of development and disease Section V. Disease Models and Behavior Genetic Applications 20. Acute and chronic alcohol effects in zebrafish 21. Behavioural genetics of embryonic ethanol exposure in zebrafish: A model for FASD 22. Life, death, and regeneration of zebrafish dopaminergic neurons 23. Parkinson's Disease 24. Seizures and epilepsy 25. Aging, circadian clock and neurogenesis: the zebrafish approach 26. Autism models 27. Studying aggression in zebrafish 28. Methylmercury induces transgenerationally transmissible epigenetic changes influencing zebrafish behavior Section VI. Big Data and Bioinformatics 29. The design of behavioral screening in zebrafish 30. Software tools for behavioral phenotyping of zebrafish across the life span 31. The Zebrafish Genome Sequencing Project: Bioinformatics resources 32. Registered, standardized and interactive: a review of online resources for zebrafish neuroanatomy
- ISBN: 978-0-12-817528-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 800
- Fecha Publicación: 01/04/2020
- Nº Volúmenes: 1
- Idioma: Inglés