Fully updated and extensively illustrated this new edition covers each of neurological complications of AIDS. From basic science to clinical care and epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology, and the only one comprehensive enough to standalone in each segment of study in brain disorders affected by the HIV. Neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). Long-termresistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. These areassociated with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people.Fully updated from the previous two editions and replete with color images, The Neurology of AIDS, Third Edition covers each of these neurological complications and more with a focus on molecular and viral disease processes, cellularfactors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease. From basic science to clinical care, toepidemiological disease patters, The Neurology of AIDS is the only complete textbookavailable on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDSfield. Section 1. HIV-1 Biology and Immunology 1.1. HIV-1 Biology, Michael Bukrinsky and Sergey Iordanskiy 1.2. HIV-1 Immunology, Sabita Roy, Subhash Dhawan, Shilpa Buch, and Krishnakumar Devadas 1.3 Chemokines, Richard J. Miller1.4 Viral and host genetic factors, Christopher Power, Jennifer A. McCombe, Shaona Acharjee, and M. John Gill1.5 Genetic Susceptibilities in neuroAIDS, Sunil K. Ahuja, Srinivas Mummidi, Jason F. Okulicz, Edwina J. Wright, and Weijing HeSection 2. Innate and Cellular Immunity and Neurogenesis2.1. Mononuclear phagocytes, Kenneth C. Williams, William Hickey, Tricia H. Burdo, and Caroline Soulas 2.2. Microglia, Sunhee C. Lee 2.3. Astrocytes, Etty N. Benveniste, Lisa N. Akhtar, and Brandi J. Baker2.4. Adaptive Immunity, Howard E. Gendelman, Jessica A.L. Hutter, Larisa Poluektova, and Subhash Dhawan 2.5. Vaccines, R. Lee Mosley, Max V. Kuenstling, and Eric J. Benner2.6. Neurogenesis, Jialin C. Zheng, James B Reinecke, Hui Peng, Yunlong Huang, and Qiang ChenSection 3. Blood brain barrier and HIV CNS Entry 3.1. Blood brain barrier: Structure and function, William A. Banks3.2. Endothelial cell biology and HIV-1 infection, Michal Toborek, Ibolya E. Andrs, Cetewayo S. Rashid, Yu Zhong, and Shinsuke Nakagawa 3.3. Blood-brain barrier during neuroinflammation, Yuri Persidsky and ServioH. Ramirez3.4. Mechanisms of viral and cell entry into the CNS, Eliseo A. Eugenin and J.W. Berman 3.5. Monocyte-macrophages and viral CNS entry, Georgette D. KanmogneSection 4. Cellular and Viral Neurotoxicity and Abused Drugs4.1. Mononuclear phagocyte inflammation and neurotoxicity, Howard E. Gendelman, Andrea Martinez-Skinner, Ari Nowacek, and JoEllyn McMillan4.2. Neurotoxicity of HIV-1 proteins, Ruth Brack-Werner, Manja Meggendorfer, Ina Rothenaigner, Bianca Tigges, and Michelle Vincendea 4.3. HIV-1 and Tat, Avindra Nath, Wenxue Li, Guanhan Li, and Joseph Steiner4.4. HIV-1 gp120, Stuart A. Lipton, Shu-ichi Okamoto, Marcus Kaul, Ian Paul Everall, and Eliezer Masliah4.5. HIV-1 and cannabinoids, Guy A. Cabral and Erinn S. Raborn 4.6. HIV-1 and METH, Howard S. Fox4.7. HIV-1 and Opioids, Toby K. Eisenstein, Jessica Breslow, Changcheng Song,Mathew J. Finley, William D. Cornwell, Sumedha Chugh, Joseph J. Meissler, andThomas J. Rogers 4.8. HIV-1 and Cocaine, Shilpa J. Buch, Honghong Yao, and Sabita RoySection 5. Animal models5.1. SIV, Janice E. Clements, M. Christine Zink, Joseph L. Mankowski, David R. Graham, and Lucio Gama5.2. FIV, Rick B. Meeker5.3. CAEV, Valgerdur Andrsdttir, Sigurbjrg Torsteinsdttir, and Gudmundur Georgsson5.4. Transgenics, Sulie L. Chang and Marley D. Kass5.5. Immunodeficient mice, Larisa Poluektova5.6. SIV and opiates, Shilpa J. Buch, Shannon Callen, Paul Cheney, and Anil Kumar5.7. SIV and FIV and peripheral neuropathy, Joseph L. Mankowski, Victoria A. Laast, Gigi Ebenezer, and Justin C. McArthur5.8. Animal models and bioimaging, R. Gilberto Gonzlez, Eva-Maria Ratai, and Margaret R. LentzSection 6. Personal Perspectives in Living with HIV/AIDS6.1. Darren Kane6.2. Eric Glare6.3. James May6.4. Karen6.5. Susan PaxtonSection 7. Clinical and Pathologic Manifestations of Disease7.1. Prospective on HIV CNS Infections, Richard W. Price7.2. HAND, Igor Grant and Ned Sacktor7.3. Early Manifestations of CNS Disease, Serena S. Spudich7.4. HIV-1 Neuropathology, Benjamin B. Gelman and David J. Moore7.5. Peripheral Neuropathy, David M. Simpson, Kathryn J. Elliott, and Justin McArthur7.6. Spinal Cord Disease, Christina M. Marra7.7. Myopathy, Susan Morgello, Jessica Robinson-Papp, Kenneth A. Fox, and David M. Simpson7.8. Aging, Christian L. Achim and Virawudh Soontornniyomkij7.9. Addiction, R. Douglas BruceChapter 8. Pathogenesis of Co-Morbid Conditions8.1. NeuroAIDS as an Inflammatory Disorder, Dennis L. Kolson, Denise R. Cooka, Stephanie A. Crossa, and Samantha S. Soldana8.2. Neuronal Injury, White Matter Disease, and Neurotrophic Factors, Dianne Langford, Eliezer Masliah, and Ian Paul Everall8.3. Pathobiology of HIV-related neuropathies, BJ Brew and NWS Davies8.4. CNS Co-morbidities, Georgette D. Kanmogne and David B. Clifford8.5. Opportunistic Infections, Joseph R. Berger and Bruce A. Cohen8.6. PML, Eugene O. Major and Maria Chiara G. Monaco8.7. Neoplasms, Alexis Demopoulos and Lauren Abrey8.8. Hepatitis C, Wenzhe Ho and Li Ye8.9. Psychiatric Co-Morbidities, Ian Paul Everall and Timothy B. NguyenChapter 9. Diagnostics and Biomarkers9.1. Brain Imaging, Linda Chang, Ute Feger, and Thomas Ernst, Ph.D.9.2. MRI, Terry L. Jernigan, Sarah L. Archibald, and Christine Fennema-Notestine9.3. Psychological Evaluations, Steven Paul Woods, Jordan Elizabeth Cattie, and Igor Grant9.4. Viral and Cellular Biomarkers During Antiretroviral Therapy, Scott L. Letendre9.5. Viral Dynamics, Ronald J. Ellis and Davey M. Smith9.6. Viral Clades, Avindra Nath and Wenxue Li9.7. Proteomics and Biomarkers, Pawel Ciborowski, Gwenael Pottiez, and Jayme WiederinChapter 10. Children and Adolescents10.1. Clinical and Pathological Features of HIV-1 Encephalopathy in Children and Adolescents, Mark Mintz, Leroy Sharer, and Lucy Civitello10.2. Infants, Children and Adolescents Nervous System Disease in the era of combination antiretroviral therapy, Annelies Van Rie and Anna Dow10.3. Psychosocial Aspects of Neurologic Impairment in Children with AIDS, Lori Wiener and Claude Mellins10.4. Growing up with HIV Disease, Lynnae Schwartz, Leslie K. Serchuck, and Shirley F. DelairChapter 11. Antiretroviral and Adjunctive Therapies11.1. Current Concepts in the Treatment of HIV Infection with Focus on Brain Disease, Susan Swindells and Uriel Sandkovsky11.2. Pharmacology of Antiretroviral Therapies, J. Allen McCutchan, Scott Letendre, Ronald J. Ellis, Brookie Best, and Edmund Capparelli11.3. Treatment of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection, David B. Clifford11.4. Nanoformulated Medicines, Howard E. Gendelman, Upal Roy, Shantanu Balkundi, and JoEllyn McMillan11.5. Antiretroviral nanotherapies, Madhavan P.N. Nair and Zainulabedin M. Saiyed11.6. Adjunctive Medicines, Harris A. Gelbard and Stuart A. LiptonChapter 12. Psychiatry and Psychobiology12.1. Psychiatric Disorders, J. Hampton Atkinson, Nichole A. Duarte, and Glenn Treisman12.2. Neuropsychiatry of Substance Abuse, Eileen M. Martin-Thomas, Andy Levine, and Raul Gonzalez12.3. Psychobiology of Risk Behavior, David G. Ostrow12.4. Everyday Impact of HIV-Associated Neurocognitive Disorders, Thomas D. Marcotte, J. Cobb Scott, Charles H. Hinkin, and Robert K. Heaton12.5. Facing Legal and Ethical Challenges in the Treatment of AIDS, Glenn J. Treisman and Warren B. Treisman12.6. Neuropsychological Testing, Kevin R. Robertson, Kevin J. Liner, Michelle Ro, and Robert K. Heaton12.7. The impact of HIV subtype, cultural, and sociodemographic factors on HIV-1 infection and associated neuropathogenesis in Africa, Charles Wood, Adelina Holguin, and Damien C. Tully
- ISBN: 978-0-19-539934-9
- Editorial: Oxford University
- Encuadernacion: Cartoné
- Páginas: 1160
- Fecha Publicación: 08/12/2011
- Nº Volúmenes: 1
- Idioma: Inglés