The purpose of this reference work is to promote research in the pharmacologyand immunology of the neuroimmune system and to increase awareness, understanding, prevention and treatment of neuroimmune disorders. Neuroimmunopharmacology is a new ‘catch phrase’ coupling pharmacology, neuroscience and immunology as scientists, researchers and clinicians are now using the immune system to provide pharmacological intervention into neurodegenerative diseases (or brain disease). The book provides a comprehensive overview of timely topics coveringthe relationships between the immune system and the pathogenesis of neurodegenerative disorders. Recent works from laboratory, animal model and human studies strongly suggest that a major part of the disease process in Alzheimer’s and Parkinson’s Diseases, Amyotrophic Lateral Sclerosis, HIV-1-assocaited dementia, and Prion disease come from changes in the innate and adaptive arms of thebrain and peripheral immune systems. Features authors who are some of the foremost investigators in the field of neuroimmune pharmacology. Reviews topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Includes an accompanying CD-ROM with access to lectures,slide presentations, and question and answers on neuroimmune pharmacology INDICE: From the contents Preface.- Abbreviations.- Introducing Neuroimmune Pharmacology.- Section 1: Immunology of The Nervous System.- Innate and adaptive Immunity in Health and Disease.- Networks: Structure and Function of the Nervous System.- The Blood-Brain Barrier: Structure and Function.- Astrocytes,Oligodendrocytes and Schwann Cells: Biology And Function.- Macrophages, Microglia and Dendtric Cells: Biology and Function.- Neuronal and Glial Signaling.-Lymphocytes and the Nervous System.- Stem Cells and Neurogenesis In Brain Development and Therapy for Neurodegenerative Disorders.- Molecular Neurobiology.- Neurobiology and Neural Systems.- The Relevance of Cytokines and Chemokines in the Pathogenesis of Neurodegenerative Disorders.- CNS Cell Signaling: Homeostasis, Disease and Repair.- Section 2: Nervous System Diseases and Immunity: Clinical Descriptions.- Neurodegeneration.- Neuroimmunologic Diseases.- Multiple Sclerosis and other Demyelinating Diseases.
- ISBN: 978-0-387-72572-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 1005
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés