Platelet proteomics: principles, analysis, and applications

INDICE: Preface by Ángel and García ad Yotis A. Senis. Foreward by Steve P.Watson. Part I. General overview: platelets, sample preparation and mass spectrometry-based proteomics. 1.Platelets and their role in thrombotic and cardiovascular disease: the impact of proteomic analysis (Ronald Stanley and Jon Gibbons). 2. Mass spectrometry-based proteomics: General overview, and PTMs analysis in the context of platelet research (Julia Burkhart and Albert Sickmann). 3. Sample preparation variables in platelet proteomics for biomarker research (Maria Zellner and Rudolf Oehler). Part II. Analysis of the platelet proteome:Global approaches and sub-proteomes. 4. Two-dimensional gel electrophoresis: Basic principles and application to platelet signaling studies (Ángel García).5. The platelet membrane proteome (Yotis A. Senis). 6. Organellar proteomics and the analysis of the platelet releasate (James McRedmond). 7. The platelet microparticle proteome (David Smalley). 8. N-terminal COFRADIC analysis of thehuman platelet proteome (Kris Gevaert et al.). Part III. Integrated omics andapplication to disease. 9. SAGE to study the platelet and megakaryocyte transcriptome (Mike Tomlimson). 10. The application of microarray analysis and its integration with proteomics to study platelet-associated disorders (Wadie Bahou and Dimitri Gnatenko). 11. Platelet Functional Genomics (Isabelle I. Salles et al.) 12. The Systems Biology to study platelet-related bleeding disorders (Jan Willem Akkerman and Bernard de Bono). 13. Platelet Proteomics in Transfusion Medicine (Andreas Greinacher and Thomas Thiele). 14. Cardiovascular proteomics (Fernando Vivanco et al.).

• ISBN: 978-0-470-46337-6
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 352
• Fecha Publicación: 15/03/2011
• Nº Volúmenes: 1
• Idioma: Inglés