An accurate, inexpensive, and noninvasive method for the early diagnosis of cancer has been something of a holy grail among cancer researchers, but until recently a method meeting all three criteria has been elusive. Nucleic acids were first discovered in circulation in 1948, but it was not until the 1960s and70s that patients with autoimmune disease and cancer were discovered to have higher levels of circulating DNA than were detected in in healthy persons. INDICE: Preface: Peter B. Gahan and R. Swaminathan Circulating Nucleic Acids in Plasma and Serum: Recent Developments: Peter B. Gahan and R. SwaminathanPart I. Basic Research:1. Metabolic DNA as the Origin of Spontaneously Released DNA?: Peter Gahan, Philippe Anker, and Maurice Stroun2. Circulating DNA: ItsOrigin and Fluctuation: Maniesh van der Vaart and Piet J. Pretorius3. The Origin of Elevated Levels of Circulating DNA in Blood Plasma of Premature Newborns: N. O. Tuaeva, Z.I. Abramova and V. V. Sofronov4. The Effect of Protein Transport Inhibitors on the Production of Extracellular DNA: Evgeniy S. Morozkin, Tatyana I. Babochkina, Valentin V. Vlassov, and Pavel P. Laktionov5. Binding and Penetration of Methylated DNA into Primary and Transformed Human Cells: Tatyana E. Skvortsova, Valentin V. Vlassov, and Pavel P. Laktionov6. Extracellular DNA Fragments: Factors of Stress Signalling between X-irradiated and Non-irradiated Human Lymphocytes: Aleksei V. Ermakov, Svetlana V. Kostyuk, Marina S. Konkova, Natalya A. Egolina, Elena M. Malinovskaya, and Natalya N. Veiko7. Isolation and Sequencing of Short Cell-Surface-Bound DNA: Vera S. Mal'shakova, Dmitry V. Pyshnyi, Alexander A. Bondar, Valentin V. Vlassov, and Pavel P. Laktionov8. Extracellular RNA Spontaneously Internalized by Human Cells Undergo Deamination of Adenosines: Elena V. Kuligina, Oksana V. Vratskih, Dmitry V. Semenov, Vera A. Matveea, and Vladimir A. Richter9. Circulating Nucleic Acids in theAssessment of Endogenous Growth Hormone Production: H. Thakkar, A.N. Butt, J.Powrie, R. Holt, and R. Swaminathan10. The Involvement of Different Mobile Line Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response: Sophiya S. Sherlina and Viktor G. VladimirovPart II. Methodology:11. Transrenal Nucleic Acids from Proof-of-Principle to Clinical Tests: Problems and Solutions: Hovsep S. Melkonyan, W. John Feaver, Erik Meyer, Vladimir Scheinker, Eugene M. Shekhtman, Zhenghan Xin, and Samuil R. Umansky12. Removal of High Molecular Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of Mutated K-ras DNA in Urine: Ying-Hsiu Su, Janet Song, Zhili Wang,Xiao-He Wang, Mengjun Wang, Dean E. Brenner, and Timothy M. Block13. A Methodfor Characterization of Total Circulating DNA: Maniesh van der Vaart and PietJ. Pretorius14. Isolation and Extraction of Circulating Tumour DNA from Patients with Small Cell Lung Cancer: Ruth E Board, Victoria S Williams, Lucy Knight , Jacqueline Shaw, Alastair Greystoke, Malcolm Ranson, Caroline Dive, Fiona H Blackhall, and Andrew Hughes15. Stability of ?-Actin mRNA in Plasma: N.C. Holford, H.S. Sandhu, H. Thakkar, A.N. Butt, and R. Swaminathan16. Normalizationof Circulating Nucleic Acid Results. Should We Use ?-Actin?: N.C. Holford, A.Ramoutar, A.N. Butt, and R. Swaminathan17. Artificial BOX C/D RNA Targeted toBranch Point Adenosine Impairs Splicing by Exon Exclusion: Dmitry V. Semenov,Oksana V. Vratskih, Elena V. Kuligina, and Vladimir A. Richter18. Optimization of Purification of Human Cell-free mRNA from Plasma: Tadeja Dovc-Drnovsek, Barbara Emersic, Primoz Rozman, Darko Cerne, and Jana Lukac-Bajalo19. Fragmentsof Non-coding RNA in Plasma of Human Blood: Dmitry V. Semenov, Dmitry N. Baryakin, Tatyana P. Kamynina, Elena V. Kuligina, and Vladimir A. Richter20. An Improved Method for the Isolation of Free-circulating Plasma DNA and Cell-free DNA from Other Body Fluids: Christoph Kirsch, Sabine Weickmann, Bernd Schmidt, and Michael FleischhackerPart III. Fetal Nucleic Acids:21. Fetal Nucleic Acidsin Maternal Plasma: Towards the Development of Noninvasive Prenatal Diagnosisof Fetal Chromosomal Aneuploidies: Y.M. Dennis Lo22. Phenotype and mRNA Expression of Syncytiotrophoblast Microparticles Isolated from Human Placenta: Belinda Kumpel, May-Jean King, Suren Sooranna,Dave Jackson, Jane Eastlake, Rong Cheng, and Mark Johnson23. Fetal Sex Identification in Maternal Plasma Using Dhort Tandem Repeats on Chromosome X: Gennaro Vecchione, Michela Tomaiuolo, Michelina Sarno, Donatella Colaizzo,Rosella Petraroli, Maria Matteo, Pantaleo Greco, Elvira Grandone, and Maurizio Margaglione24. A New Y-chromosome Marker for Noninvasive Fetal Gender Determination: Olga B. Vainer, Aleksey V. Katokhin, Sergey M. Kustov , Valentin V. Vlassov, and Pavel P. LaktionovPart IV. Circulating Nucleic Acids and Cancer:25. DNA Integrity in Plasma and Serum of Patients with Malignant and Benign Diseases: Stefan Holdenrieder, Alexander Burges, Oliver Reich, Fritz W. Spelsberg, and Petra Stieber26. Quantification of LINE1 inCirculating DNA as a Molecular Biomarker of Breast Cancer: Eiji Sunami, Anh-Thu Vu, Sandy L. Nguyen, Armando E Giuliano, and Dave S. B. Hoo27. Effect of Adjuvant Chemotherapy on Integrity of Free Serum DNA in Patients with Breast Cancer: Ugur Deligezer, Yesim Eralp, Elif Z. Akisik, Ebru E. Akisik, Pinar Saip,Erkan Topuz, and Nejat Dalay28. Clinical Relevance of Circulating Nucleosomes in Cancer Disease: Stefan Holdenrieder, Dorothea Nagel, Andreas Schalhorn, Volker Heinemann, Ralf Wilkowski, Joachim von Pawel, Hannelore Raith, Knut Feldmann, Andreas E Kremer, Susanne Müller, Sandra Geiger, Gerhard F Hamann, DietrichSeidel, and Petra Stieber 29. Detection and Monitoring of Cell-Free DNA in Blood of Patients with Colorectal Cancer: Heidi Schwarzenbach, Jan Stoehlmacher,Klaus Pantel, and Eray Goekkurt30. Detection of Mutated K-ras DNA in Urine, Plasma and Serum from Patients with Colorectal Carcinoma or Adenomatous Polyps:Ying-Hsiu Su, Mengjun Wang, Dean E. Brenner, Pamela A. Norton, and Timothy M.Block31. Integrity of Cell-free Plasma DNA in Patients with Lung Cancer and Non-malignant Lung Disease: Bernd Schmidt, Sabine Weickmann, Christian Witt, and Michael Fleischhacker32. Cell-surface-bound Circulating DNA as A Prognostic Factor of Lung Cancer: Svetlana N. Tamkovich, Nikolai V. Litviakov, Olga E. Bryzgunova, Aleksey Yu. Dobrodeev, Elena Yu. Rykova, Sergey A. Tuzikov, Aleksandr A. Zav'ialov, Valentin V. Vlassov, Nadezhda V. Cherdyntseva, and Pavel P. Laktionov33. Deoxyribonuclease Activity and Circulating DNA Concentration in Blood Plasma of Prostate Tumor Patients: Anna V. Cherepanova, Svetlana N. Tamkovich, Olga E. Bryzgunova, Valentin V. Vlassov, and Pavel P. Laktionov34. Methylation-specific Sequencing of GSTP1 Gene Promoter in Circulating/Extracellular DNA from Blood and Urine of Healthy Donors and Prostate Cancer Patients: Olga E. Bryzgunova, Evgeniy S. Morozkin, Sergey V. Yarmoschuk, Valentin V. Vlassov, and Pavel P. Laktionov35. Circulating DNA in the Blood of Gastric Cancer Patients: Elena V. Kolesnikova, Svetlana N. Tamkovicha, Olga E. Bryzgunova, Petr I.Shelestyuk, Valentina I. Permyakova, Aleksandr S. Tuzikovd, Valentin V. Vlassov, Pavel P. Laktionov, and Elena Y. Rykova36. Methylation-based Analysis of Circulating DNA for Breast Tumors Screening: Elena Y. Rykova, Galina A. Tsvetovskaya, Galina I. Sergeeva, Valentin V. Vlassov, and Pavel P. LaktionovPart V. Circulating Nucleic Acids and Other Diseases:37. Overview of Circulating Nucleic Acids in Plasma/Serum: Update on Potential Prognostic and Diagnostic Value in Pathology Excluding Fetal Medicine and Oncology: Asif N. Butt and R. Swaminathan38. Effect of Hypoxia on Circulating Levels of Retina Specific Messenger RNA in Type 2 Diabetes Mellitus: Amy Wong, Simon Merritt, Asif N. Butt, AdrianWilliams, and R. Swaminathan39. Retinal Specific mRNA in the Assessment of Diabetic Retinopathy: Z. Shalchi, H. S. Sandhu, A.N. Butt, S. Smith, J. Powrie, and R. Swaminathan40. Measurement of circulating Neuron Specific Enolase mRNA in Diabetes Mellitus: H. S. Sandhu, A.N. Butt, J. Powrie, and R. Swaminathan41.Hepatitis B Virus X-DNA: A Serum Marker for Early Detection of Resistance Development during Lamivudine Therapy: Wei Zhang, Yan-Hong Li, Shao-Jun Zhu, Yan Zhang, Li Gong, Shu-Mei Wang, Hans J”rg Hacker, Claus Hobe Schr”der, Dong-Sheng Cheng, and Ying-Ming Feng42. Cell - free DNA of Patients with Cardiomyopathyand rDNA Alone Change the Frequency of Contraction of the Electrically Paced Neonatal Rat Ventricular Myocytes in Culture: N. Bulicheva, O. Fidelina, N. Mkrtumova, M. Neverova, A. Bogush, M. Bogush, O. Roginko, and N. Veiko 43. Influence of Plasma DNA on Acid-base Balance, Blood Gas Measurement, and Oxygen Transport in Health and Stroke: Irina L. Konorova, Natalya N. Veiko, and Viktor E. Novikov44. Circulating 11?-Hydroxysteroid Dehydrogenase Type 1 mRNA and Cardiovascular Risk Factors: Maise Al Bakir, Asif Butt, and R. Swaminathan45. Hypertension and circulating mRNA for 11?-Hydroxysteroid Dehydrogenase Type II: S.Agalou, A. Butt, Phil Chowienczyk, and R. Swaminathan46. Cell-free Plasma DNAduring Peritoneal Dialysis, Hemodialysis, and in Patients with Chronic KidneyDisease: Marie Korabecna, Sylvie Opatrna, Jan Wirth, Kamila Rulcova, Jan Eiselt, Frantisek Sefrna, and Ales Horinek 47. Arrayed Primer EXtension (APEX) forthe Non-Invasive Prenatal Diagnosis of ?-thalassaemia Based on Detection of Single Nucleotide Polymorphisms: Thessalia Papasavva, Ioannis Kalikas, Andreanni Kyrri, and Marina Kleanthous48. The Housekeeping Gene (ga3pdh) and the Long Interspersed Nuclear Element (line) in the Blood and Organs of the Rats Treated with Cocaine: Anatoliy M. Voskresenskiy and Lena S. Sun49. Extracellular Functional Non-Coding Nucleic Acid Bioaptamers and Angiotropin RNP Ribokines in Vascularization and Self-Tolerance: 3D-Episcripts on Domains Shared in Regulator Proteins of the Vascular and Cancer Epigenome: Josef H. Wissler, Joerg E. Wissler, and Enno LogemannIndex of Contributors
- ISBN: 978-1-57331-734-4
- Editorial: New York Academy of Science
- Encuadernacion: Rústica
- Páginas: 352
- Fecha Publicación: 01/10/2008
- Nº Volúmenes: 1
- Idioma: Inglés