Tumor induced immune suppression: mechanisms and therapeutic reversal

There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches totheir correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance. Presents a comprehensive overview of different mechanisms of immune dysfunction. Discusses a number of new mechanisms that have never been discussed in a monogragraph report including: T-cell inhibitory molecules and regulatory tolergenic DCs. Focus on therapeutic correction of the observed abnormalities INDICE: From the contents Introduction.- Mechanisms and Therapeutic Reversal of the Defects in T-Cell Function in Cancer.- Molecular Mechanisms of Tumor-Associated T-Cell Tolerance.- T-Cell Tolerance.- T-Cell Inhibitory Molecules and Suppression of T-Cell Function In Cancer.- CTLA-4 and T-Cell Tolerance in Cancer.- Regulatory T-Cells in Cancer.- T-Cell Apoptosis in Cancer.- Defects in Dendritic Cell Differentiation in Cancer and Tumor Escape.- Dendritic Cells With Tolerogenic Potential in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in Induction of T-Cell Tolerance.- Macrophages and Tumor Development.- Immature Myeloid Suppressor Cells in Tumor-Induced T-Cell Tolerance.- Arginin Metabolism as A Critical Element of Tumor Suppression in Cancer.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Cytokine Production in Cancer and their Negative Effect on Immune Response.

• ISBN: 978-0-387-69117-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 575
• Fecha Publicación: 01/01/2008
• Nº Volúmenes: 1
• Idioma: Inglés