Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. This reference then defines the exciting research in recent years how a much wider spectrum of sources, targets and functions have been identified, showing that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues. This reference reaches a wide academic audience with a broad interest in biomedical sciences, including: Endocrinology: FGF23 initially identified as a bone-derived factor targeting the kidneyPhysiology: FGF23 as a regulator of phosphate metabolism and beyondCell Biology: Mechanistic FGF23 research revealed novel concepts of FGF receptor signalingBiochemistry: Molecular crosstalk between FGF23 and klotho, from structure and binding to signal transductionPharmacology: FGF23 and its receptors as potential drug targets to treat or prevent diseases, such as CKD, heart failure or COPDBasic Research: Cell culture and animal models as well as novel assays to study FGF23 production and effectsNephrology: FGF23 as a biomarker and cause for CKD and associated pathologiesInternal Medicine: FGF23 as a biomarker and cause for various diseases involving the kidney, heart, lung and liver Provides a comprehensive collection of chapters describing the diversity of FGF23's actionsHighlights truly translational topics as they range from molecular signaling to physiology and to mechanism of disease, discussing cell culture and animal models to study FGF23Describes FGF23's potential in the clinical setting, as a biomarker or even drug targetLeaders in the field cover a wide spectrum of research background and expertise, including clinical and basic scientists, with expertise in studying various diseases and in endocrinology, genetics, protein biochemistry, cell biology and physiology INDICE: 1. The discovery of FGF23 - a historic view: genetic disorders of hypo- and hyperphosphatemia 2. FGF23 - an established master regulator of phosphate metabolism 3. FGF23 - more than a phosphaturic hormone 4. The regulation of FGF23 production in bone and outside of bone 5. Klotho-dependent actions of FGF23 - targets, signal transduction and cellular effects 6. Klotho-independent actions of FGF23 - targets, signal transduction and cellular effects 7. The experimental detection of FGF23 responsiveness and effects 8. FGF23 and bone disease 9. FGF23 and kidney disease 10. FGF23 and heart and vascular disease 11. FGF23 and inflammation, anemia, and iron 12. FGF23 and infectious diseases 13. FGF23 and lung disease 14. FGF23 and neuro-cognitive disorders 15. FGF23 measurements in humans and its place as a clinical biomarker 16. FGF23 - a drug target including treatment of hypophosphatemic osteomalacia 17. FGF23 - resolved issues, remaining controversies and future questions - a clinician's perspective 18. Klotho - the discovery of the FGF23 co-receptor 19. Klotho - an FGF23-independent hormone 20. Klotho and aging phenotypes 21. ?Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease 22. Structural Basis of FGF23 Hormone Signaling 23. Klotho - open questions, controversies and future perspectives 24. The crosstalk between phosphate, FGF23 and klotho in the regulation of tissue homeostasis in health and disease
- ISBN: 978-0-12-818036-5
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 475
- Fecha Publicación: 01/09/2020
- Nº Volúmenes: 1
- Idioma: Inglés