Brain Lipids in Synaptic Function and Neurological Disease: Clues to Innovative Therapeutic Strategies for Brain Disorders

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. *Written to provide a hands-on approach for readers*Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings*Step-by-step guide to memorize and draw lipid structures*Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique INDICE: Part I. Brain Lipids Chapter 1. Chemical basis of lipid biochemistry Chapter 2. Brain membranes   Chapter 3. Lipid metabolism and oxidation in neurons and glial cells Chapter 4. Variations of brain lipid content Part II. Brain Lipids and Synaptic Functions Chapter 5. A molecular view of the synapse Chapter 6. Lipid-protein interactions in the brain Chapter 7. Lipid regulation of receptor function Part III. Brain Lipids and Neurodegenerative Disease Chapter 8. Common mechanisms in neurodegenerative disease Chapter 9. Creutzfeldt-Jakob's disease Chapter 10. Parkinson's disease Chapter 11. Alzheimer's disease Part IV. Brain Pathogens and Amyloidogenic Proteins: The Lipid Connection Chapter 12. Viral and bacterial diseases Chapter 13. A unifying theory Conclusion Glossary

• ISBN: 978-0-12-800111-0
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 13/10/2015
• Nº Volúmenes: 1
• Idioma: Inglés