Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs) Discusses the state–of–art methods for CTC isolation, ranging from the macro– to micro–scale, from positive concentration to negative depletion, and from biological–property–enabled to physical–property–based approaches Details commercially available CTC platforms Describes post–isolation analysis and clinical translation Provides a glossary of scientific terms related to CTCs INDICE: Preface .Part I Introduction .1 Circulating tumor cells and historic perspectives Jonathan W. Uhr .2 Introduction to microfluidics Kangfu Chen, Z. Hugh Fan .Part II Isolation Methods .3 Ensemble–decision Aliquot Ranking (eDAR) for CTC Isolation and Analysis Mengxia Zhao, Perry G. Schiro, Daniel T. Chiu .4 Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis Joshua M. Jackson, Steven A. Soper, Ma gorzata A. Witek .5 Cell Separation Using Inertial Microfluidics Nivedita Nivedita, Ian Papautsky .6 Morphological Characteristics of CTCs and the Potential for Deformability–based Separation Simon P. Duffy, Hongshen Ma .7 Microfabricated filter membranes for capture and characterization of Circulating Tumor Cells Zheng Ao, Anthony Williams, Richard J. Cote, Ram H. Datar .8 Miniaturized Nuclear Magnetic Resonance Platform for Rare Cell Detection and Profiling Sangmoo Jeong, Changwook Min, Huilin Shao, Arezou Ghazani, Cesar M. Castro, Ralph Weissleder, Hakho Lee .9 NanoVelcro Cell–Affinity Assay for Detection and Characterization of Circulating Tumor Cells An–Jou Liang, Anna Fong, Hsian–Rong Tseng, Jie–fu Chen, Millicent Lin, Min Song, Morgan Fong, Qingyu Li, Shang–Fu Chen, Sharon Chen, Shuang Hou, Yang Zhang, Zunfu Ke .10 Acoustophoresis for tumor cell enrichment Thomas Laurell, Per Augustsson, Cecilia Magnusson, Hans Lilja .11 Photoacoustic flow cytometry for detection and capture of circulating melanoma cells John A. Viator, Benjamin S. Goldschmidt, Kiran Bhattacharyya, Kyle Rood .12 Selectin–Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment Jocelyn Marshall, Michael King .13 Aptamers–enabled tumor cell isolation Jinling Zhang, Z. Hugh Fan .14 Depletion of normal cells for CTC enrichment Jeffrey J. Chalmers, Maryam B. Lustberg, Clayton Deighan, Kyoung–Joo Jenny Park, Yongqi Wu, Peter Amaya .Part III Post–Isolation Analysis and clinical translation .15 Tumor heterogeneity and single cell analysis of CTCs Evelyn Kidess Sigal, Stefanie S. Jeffrey .16 Single–cell molecular profiles and biophysical assessment of circulating tumor cells Chun–Liang Chen, Maria E. Gaczynska, Aaron M. Horning, Chun–Lin Lin, Anna D. Louis, Devalingam Mahalingam, Pawel Osmulski, Chiou–Miin Wang .17 Directing Circulating Tumor Cell Technologies into Clinical Practice Benjamin P Casavant, David T Kosoff, Joshua M Lang .Part IV Commercialization .18 DEPArray Technology for Single CTC–analysis Farideh Z. Bischoff, Nicolò Manaresi, Gianni Medoro .19 CELLSEARCH® instrument, features, and usage Denis A. Smirnov, Brad W. Foulk, Mark C. Connelly, Robert T. McCormack .Glossary Jose Varillas, Z. Hugh Fan .Index
- ISBN: 978-1-118-91553-0
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 496
- Fecha Publicación: 27/05/2016
- Nº Volúmenes: 1
- Idioma: Inglés