This volume will provide researchers with recent information on bioactivationreactions of drugs and toxicants and will provide examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections of this volume, focus will be on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences. In these sections, the contributors will demonstrate the integration of bioactivation research in several research areas, including new drug design, drug development, mechanisms of cell death, toxicity and carcinogenicity, metabolite-specific biomarkers of exposure and effect, and extrapolations of results from animal models to humans. Provides researchers with recent information on bioactivation reactions of drugs and toxicants INDICE: From the contents General Concepts and Basic Mechanisms.- Metabolic Concerns in Drug Design.- Role of Bioactivation in Idiosyncratic Drug Toxicity.- Michael Addition-Elimination Reactions.- Induction of Drug Metabolizing Enzymes.- Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes.- CYP2E1-Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury.- One and Two Electron Mediated Reduction of Quinones.- Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates.- Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes.- TISSUE-Specific Features And Risk Assessment Applications.- Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death.- Hepatic Bioactivation and Drug-Induced Liver Injury.- Role of Cysteine S-Conjugate ß-Lyases in the Bioactivation of Renal Toxicants.
- ISBN: 978-0-387-77299-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 450
- Fecha Publicación: 01/06/2008
- Nº Volúmenes: 1
- Idioma: Inglés