This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences. INDICE: Introduction & Overview of mitochondrial drug toxicity SECTION 1: BASIC CONCEPTS Chapter 1: Basic mitochondrial physiology Chapter 2: Basic molecular biology of mitochondrial replication Chapter 3: Drug-associated mitochondrial toxicity Chapter 4: Pharmacogenomics of mitochondrial drug toxicity SECTION 2: ORGAN DRUG TOXICITY - MITOCHONDRIAL ETIOLOGY Chapter 5: Hepatotoxicity Chapter 6: Cardiovascular Toxicity Chapter 7: Skeletal Muscle Chapter 8: Nervous system Chapter 9: Lipoatrophy Chapter 10: Nephrotoxicity Chapter 11: Drug effects in patients with mitochondrial diseases SECTION 3: ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO & IN VIVO Chapter 12: Polarography Chapter 13: Fluorescent probes Chapter 14: Fluorescent solid phase sensors Chapter 15: Coupled enzyme reactions Chapter 16: Teathered antibody in vitro, dipstick technology in vivo Chapter 17: Membrane potential and Permeability Transition Chapter 18:Free radical production Chapter 19: Protein synthesis Chapter 20: mtDNA as index of antiviral therapy Chapter 21: Function via 13C-methionine exhalation Chapter 22: Function via microscopy Chapter 23: Development of animal models Chapter 24: Imaging Chapter 25: Mito Drug Delivery
- ISBN: 978-0-470-11131-4
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 616
- Fecha Publicación: 10/10/2008
- Nº Volúmenes: 1
- Idioma: Inglés