Functional Neural Transplantation IV: Translation to Clinical Application, Part A

Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Comprehensive set of critical reviews covering the fieldPresents state-of-the-art topics in science and translational medicineWritten by international leaders in the field of neural transplantation INDICE: 1. Mechanisms and use of neural transplantation for brain repair    S.B. Dunnett & A. Björklund 2. Reprogramming of somatic cells: iPS and iN cells    V. Brocolli 3. Brain repair from intrinsic cell source3s: Turning reactive glia into neurons    O. Torper & M. Götz 4. Cell transplants as delivery vectors    G. Gowing, S. Svendsen & C.N. Svendsen 5. Preparation, characterisation and banking of clinical grade cells for neural transplantation: scale up, fingerprinting and genomic stability of stem cell lines    A. Natalwala & T. Kunath 6. Regulatory considerations for pluripotent stem cell therapies    M.K. Carpenter 7. Strategies for bringing stem cell derived dopamine neurons to the clinic - a European approach (STEM-PD)    A. Kirkeby, M. Parmar & R. Barker 8. Strategies for bringing stem cell derived dopamine neurons to the clinic - the NYSTEM trial    L. Studer 9. Strategies for bringing stem cell derived dopamine neurons to the clinic - the Kyoto trial    J. Takahashi 10. Lessons learned from managing Multicentre clinical trial   in Huntington´s disease    A.C. Bachoud-Lévi 11. Development of pluripotent stem cells for transplantation in Huntington´s disease    A.E. Rosser & M. Li 12. Advanced imaging of transplant survival, fate, differentiation and integration    N. Van Camp, E. Diguet & P. Hantraye 13. The biological substrate for neurorehabilitation    S. Clinch, M. Busse, M.D. Döbrössy & S.B. Dunnett

• ISBN: 978-0-12-811738-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 358
• Fecha Publicación: 01/06/2017
• Nº Volúmenes: 1
• Idioma: Inglés