Heteroaromatic lipoxin A4 analogues: synthesis and biological evaluation

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxinanalogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analoguesfor biological evaluation. Nominated by University College Dublin as an outstanding PhD thesis. Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4. Description of an excellent route to a thiophene-containing LXA4 analogue INDICE: Introduction. Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues. Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues. Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues. Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines. Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.

• ISBN: 978-3-642-24631-9
• Editorial: Springer Berlin Heidelberg
• Encuadernacion: Cartoné
• Páginas: 127
• Fecha Publicación: 30/11/2011
• Nº Volúmenes: 1
• Idioma: Inglés