Novel Delivery Systems for Transdermal and Intradermal Drug Delivery

  This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications.   Furthermore, it presents in–depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle–free injections, nanoparticulate systems and peptide–carrier–type systems. It also covers conventional physical enhancement strategies, such as tape–stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivo animal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry. INDICE: About the Editors .List of Contributors .Series Preface .Preface .Chapter 1 IntroductionGary P.J. Moss .Chapter 2 Application of spectroscopic techniques to interrogate skinJonathan Hadgraft, Rita Mateus and Majella E. Lane .Chapter 3 Analysis of the native structure of the skin barrier by cryo–TEM combined with EM–simulationLars Norlén .Chapter 4 Intradermal vaccinationMarija Zaric and Adrien Kissenpfennig .Chapter 5 Film forming and heated systemsWilliam J. McAuley .Chapter 6 Nanotechnology–Based Applications for Transdermal Delivery of TherapeuticsVenkata K Yellepeddi .Chapter 7 Magnetophoresis and Electret mediated Transdermal Delivery of drugsAbhijeet Maurya, Cui Lili and S.Narasimha Murthy .Chapter 8 Microporation for Enhanced Transdermal Drug DeliveryThakur Raghu Raj Singh?, Gujral C .Chapter 9 Microneedle TechnologyHelen L. Quinn, Aaron J. Courtenay, Mary–Carmel Kearney and Ryan F. Donnelly? .Chapter 10 Intradermal delivery of active cosmeceutical ingredientsAndrzej M. Bugaj .Chapter 11 Commercial and Regulatory Considerations in Transdermal and Dermal Medicines DevelopmentProfessor Marc .B. Brown, Jon Lenn, Charles Evans, Dr Sian Lim .Index

• ISBN: 978-1-118-73451-3
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 296
• Fecha Publicación: 04/09/2015
• Nº Volúmenes: 1
• Idioma: Inglés