Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
Donnadieu, Emmanuel
161,19 €(IVA inc.)
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.
The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
- ISBN: 978-3-319-42221-3
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 199
- Fecha Publicación: 06/09/2016
- Nº Volúmenes: 1
- Idioma: Inglés