The Retinoids: Biology, Biochemistry, and Disease

The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.  The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field,   The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids. INDICE: Section 1: Vitamin A metabolic and enzymatic pathways   . 1. Vitamin A metabolism, storage and tissue delivery mechanisms . William S. Blaner and Yang Li                                 . 2. Assimilation and conversion of dietary vitamin A into bioactive retinoids . Earl H. Harrison and Carlo dela Sena . 3. Intracellular storage and metabolic activation of retinoids: lipid droplets . Joseph L. Napoli and Charles R. Krois . 4. Evolution of the retinoic acid signaling pathway                                              . Vincent Laudet, Elisabeth Zieger and Michael Schubert . Section 2: Biochemistry and cellular biology of retinoic acid signaling   . 5. Control of gene expression by nuclear retinoic acid receptors: post translational and epigenetic regulatory mechanisms . Marilyn Carrier and Cécile Rochette–Egly . 6. Retinoic acid receptor coregulators in epigenetic regulation of target genes     . Li–Na Wei . 7. Retinoid receptors: protein structure, DNA recognition and structure–function relationships . William Bourguet and Dino Moras . 8. How the RAR–RXR heterodimer recognizes the genome . Sylvia Urban, Tao Ye and Irwin Davidson . 9. Retinoid receptor–selective modulators: chemistry, 3D structures and systems biology . Marco–Antonio Mendoza–Parra, William Bourguet, Angel R. de Lera and Hinrich Gronemeyer . 10. Use of retinoid receptor ligands to identify other nuclear receptor ligands: retinoid–related molecules are ligands for the Small Heterodimer Partner (SHP) orphan receptor . Marcia I. Dawson and Zebin Xia . 11. The dual transcriptional activity of retinoic acid . Noa Noy . 12. Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice . Lorraine J. Gudas . Section 3: Retinoic acid signaling in development   . 13. Retinoic acid signaling and central nervous system development . Malcolm Maden                                               . 14. Roles of retinoic acid in limb development . Gregg Duester . 15. Retinoic acid signaling and heart development . Stéphane Zaffran and Karen Niederreither . 16. Actions of retinoic acid in developing lung and endodermal derivatives . Wellington V. Cardoso and Felicia Chen . 17. Retinoic acid and the control of meiotic initiation . Josephine Bowles and Peter Koopman . Section 4: Retinoids and physiological functions   . 18. Retinoids in the visual cycle: new actors for an old function . Darwin Babino and Johannes von Lintig . 19. Retinoid signaling in the central nervous system . Peter McCaffery and Wojciech Krezel . 20. Retinoid turnover and catabolism: influences of diet and inflammation . A. Catherine Ross and Reza Zolfaghari . 21. Retinoids and the immune system . J. Rodrigo Mora and Makoto Iwata . 22. Retinoic acid signaling in post–natal male germ cell differentiation . Manuel Mark and Norbert B. Ghyselinck . Section 5: Retinoids, disease and therapy   . 23. Vitamin A deficiency and public health                                                                                 . Keith P. West . 24. Retinoid pathway gene mutations and pathophysiology of visual diseases      . Yaroslav Tsybovsky and Krzysztof Balczewski . 25. Retinoic acid in acute myeloid leukemias . Hugues de Thé and Pierre Fenaux  . 26. Advances on the use of retinoids in cancer therapy and prevention . Michael J. Spinella, Sarah J. Freemantle and Ethan Dmitrovsky .    

• ISBN: 978-1-118-62798-3
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 608
• Fecha Publicación: 29/05/2015
• Nº Volúmenes: 1
• Idioma: Inglés