Biosynthesis of Heterocycles: From Isolation to Gene Cluster

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application INDICE: Chapter 1 Introduction 1.1  Natural Products: Primary and Secondary Metabolites 1.2 Common Reactions in Secondary Metabolites References Chapter 2 Techniques for Biosynthesis 2.1 Isotopic Labeling 2.2 Gene Coding for Enzymes 2.3 Combinatorial Biosynthesis References Chapter 3 Three–Membered Heterocyclic Rings and their Fused Derivatives 3.1 Aziridines and Azirines 3.2 Oxiranes and Oxirenes References Chapter 4 Four–Membered Heterocyclic Rings and their Fused Derivatives 4.1 Azetidine and azetines 4.2 Oxetanes 4.3 Dithiethanes References Chapter 5 Five–Membered Heterocyclic Rings and their Fused Derivatives 5.1 Pyrroles (Including Tetrapyrroles) 5.2 Indoles 5.3 Furans 5.4 Thiophenes 5.5 Pyrazoles 5.6 Imidazoles 5.7 Thiazoles 5.8 Ditioles References Chapter 6 6–Membered Heterocyclic Rings and their Fused Derivatives 6.1 Pyridines and piperidines 6.2 Pyrans 6.3 Pyridazines 6.4 Pyrimidines 6.5 Pyrazines 6.6 Oxazines 6.7 Dioxanes References Chapter 7 Eight–Membered and larger Heterocyclic Rings and their Fused Derivatives 7.1 Azepines 7.2 Oxepanes and Oxepines 7.3 Diazepines, Oxazepines and Thiazepines 7.4  Diazocines 7.5  Oxocines 7.6 Erythromycin A 7.7 Tylosin 7.8 Zearalenone 7.9 Polyene macrolide antibiotics 7.10 Geldanamycin and Herbimycins 7.11 Rifamycins 7.12 Rapamycin References

• ISBN: 978-1-118-02867-4
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 792
• Fecha Publicación: 28/11/2014
• Nº Volúmenes: 1
• Idioma: Inglés