West nile encephalitis virus infection: viral pathogenesis and the host immune response

West Nile virus has emerged globally as a significant cause of viral encephalitis in humans. Infection of humans is associated with a febrile illness that can progress to meningitis and encephalitis with symptoms including cognitive dysfunction and flaccid paralysis. Following its introduction to the United States in 1999, West Nile virus rapidly disseminated across North America. Outbreaks of West Nile virus fever and neuroinvasive disease now occur annually in the United States, with about 23,000 diagnosed human cases between 1999 and 2006. The emergence of West Nile in the Western hemisphere and the correspondingincrease in disease burden has been accompanied by intensive study. West NileEncephalitis Virus Infection: Viral Pathogenesis and the Host Immune Responsefocuses on recent studies that have identified key steps in the molecular pathogenesis of West Nile virus infection. An in-depth look at an emerging threatto human health and safety An up-to-date compilation of current research on West Nile virus pathogenesis and immune response Contributions prepared by an internationally-renowned group of researchers INDICE: From the contents Global Epidemiology of West Nile Virus.- West Nile virus: Molecular epidemiology and diversity.- Vector biology and West Nile virus.- Clinical Manifestations of Neurological Disease.- Molecular Biology ofWest Nile Virus.- Virulence of West Nile virus in different animal hosts.- Innate immune response and mechanisms of IFN antagonism against WNV.- Innate immune responses to West Nile virus infection.- Mechanisms of Complement Regulation of Infection by Flaviviruses.- Antibody-mediated neutralization of West Nile virus: Factors that govern neutralization potency.- Structural basis of antibody protection against West Nile virus.- Molecular Mechanisms of Flaviviral Membrane Fusion.- CD4+ and CD8+ T cell immune responses in West Nile virus infection.- Enhanced antigen processing or immune evasion?- West Nile virus and the induction of immune recognition molecules.- Chemokines and Clearance of WestNile Virus Infection.

• ISBN: 978-0-387-79839-4
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 385
• Fecha Publicación: 01/10/2008
• Nº Volúmenes: 1
• Idioma: Inglés