Reverse Vaccinology: Concept, Methods and Advancement

Reverse Vaccinology: Concept, Methods, and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. This book promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur’s principles have failed, and it is explained in detail in this book.This book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, databases, network analysis, machine learning, and NGS-driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and members of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines. ? Explains the fundamentals of reverse vaccinology and how it can save time in the development of new vaccines? Focuses on the efforts to develop a vaccine candidate against various pathogens using computational approaches? Presents databases and web servers for conducting reverse vaccinology? Describes the screening process of potential vaccine candidate through machine learning INDICE: Section 1: Concept1. Fundamentals of Reverse Vaccinology: History and advantage over the discovery of conventional vaccine candidate2. Vaccine Antigen Discovery: Breakthrough in genomics eraCemal Un, Ecem Su Kockaya, Hüseyin Can3. Development of Subunit Vaccine: A step forward towards cost effective technology of vaccine candidate discoveryBabar Jamal Section 2: Tools and Methods4. Fundamentals of Machine Learning Approach for Vaccine Development Dhanalakshmi Menamadathil5. Immunoinformatic: An interdisciplinary technique for designing and engineering vaccine antigenTara Chand Yadav6. Proteomics for Epitope-vaccine DesignThiago Castro7. Data bases and Web Servers for Conducting Reverse Vaccinology Rommel Ramos8. Bacterial Dynamics and Network Analysis for Antigen Screening Flavia Figueira Aburjaile9. Tools and Platform for Allergenicity Prediction Georrge John J10. Screening of Potential Vaccine Candidate Through Machine Learning Approach Amjad Ali11. Reverse Vaccinology 2.0 Georrge John J12. Structural Vaccinology Approaches to Enhance Efficacy, Stability and Delivery of Protective Antigens Tara Chand Yadav13. NGS Driven Antigen Screening Technology in Vaccine Development Medha Pandya Section 3: Disease Case Study14. Bioinformatics Approach Design of Peptide Vaccine for Viruses Flavia Figueira Aburjaile15. Confirmation of Candidates Identified by RV in Animal Models or Other Immunogenicity Assays Helioswilton Sales-Campos16. Clinical Trials of Vaccines Incorporating Antigens Identified From an RV Approach Marcos Silva17. Review on the Development of the Meningococcal Vaccine, Bacterial Vaccines (Streptococcus, Staphylococcus) using Reverse Vaccinology Silvana Marchioro

• ISBN: 978-0-443-13395-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 600
• Fecha Publicación: 17/07/2024
• Nº Volúmenes: 1
• Idioma: Inglés