Protein Modifomics: FROM MODIFICATIONS TO CLINICAL PERSPECTIVES

Protein Modificomics: From Modification to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins including diseases involving PTM's, plant PTM's, role of therapeutic strategies and other topics such as translational proteomics. PTMs make the major backbone of several key biological processes. It has been known that many proteins often undergo unwanted modifications leading to the disruption of proteostasis and ultimately gain in disease etiology. These diseases include Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome, OFC10 etc. Cancer is also one of the major complex diseases wherein various proteins undergo undesired modifications that result in deregulation of the cell cycle, disruption of DNA repair mechanisms and also the inactivation of the proapoptotic pathways etc. Furthermore, the allosteric insight to regulation or deregulation of the protein structure due to modifications is of immense importance for designing drugs for therapeutic intervention of diseases caused due to the modifications. PTMs also play a very important role in plant physiology and production of medicinally important primary and secondary metabolites. Understanding of PTMs in plants will help us to enhance the production of these metabolites without greatly altering the genome. This will give us robust eukaryotic systems for production and isolation of desired products without considerable downstream and isolation processes. Collects in one place a thorough insight into post translational modifications (PTMs) of proteins in both the plant and animal kingdom along with current techniques involved with studying PTMsDiagrammatic representation of various protein modification and estimation mechanisms in four-colorIncludes coverage of diseases involving post translational modifications INDICE: 1. Congenital disorders of Protein Glycosylation2. Post-translational modifications in plant proteins: Role in structure and Function3. Advances in modificomics4. Role of Glycosylation in plant proteins with therapeutic importance5. Ubiquitination as a posttranslational modification: an update6. Madhu Khanna Protein homocystinylation and structural consequences7. Mass spectrometry in Post-translational modifications: an update8. Nitrosylation in Acute myeloid leukemia9. Extent of posttranslational modification in bacterial proteins10. Role of phosphorylation and regulation of enzyme function11. Effect of sumoylation in Toll-like Receptors (TLRs)12. Glycation and human diseases13. Translational plant proteomics: An Overview14. Khan Quantitative proteomics by 2DE and MALDI MS/MS in Organic farming15. Mass spectrometry for high throughput quantitative proteomics in plant research16. Quantitative mass spectrometry in functional plant proteomics with special reference to phosphoproteins17. Redox mediated post-translational modifications in plant proteins18. Promising and Empowering contributions of Proteomics to systems biology in plants

• ISBN: 978-0-12-811913-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 352
• Fecha Publicación: 01/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés