The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneeringbook is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance. Unique compilation of mitochondrial genome alterations in cancer. State-of-the-art contents. The editor is one of the leading experts in the field. INDICE: General Overview of Mitochondrial Genetics and Functions.- Mitochondrial Genetic Alterations in Cancer.- Clinical Applications of Mitochondrial Gennome Changes in Cancer.
- ISBN: 978-3-642-11415-1
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 368
- Fecha Publicación: 13/04/2010
- Nº Volúmenes: 1
- Idioma: Inglés