Wilson Diseaseprovides a comprehensive guide on this inherited genetic disorder that has devastating consequences for both the liver and neurologic/psychiatric health. This disease is of increasing interest to neurologists, hepatologists, and geneticists, but when the disease is diagnosed early, it is treatable, with patients living normal lives. This volume describes the molecular pathophysiology of WD and the clinical and pathological effects of copper. Separate sections address both diagnosis and medical and surgical approaches to treatment. Both adult and pediatric perspectives on diagnosis and treatment are addressed, and a section on genetics highlights advances in molecular diagnostics. Patient support groups that can aid in coping with this disease are also discussed, as are animal models for those interested in basic research on cell biology, pathophysiology, and treatment. Addresses the molecular pathophysiology of WD and the clinical and pathological effects of copperOffers coverage of both diagnosis and medical and surgical approaches to treatment Includes perspectives on both adult and pediatric diagnosis and treatment Edited work with chapters authored by leaders in the field from around the globe-the broadest, most expert coverage available INDICE: 1. History of Wilson's disease 2. Epidemiology of Wilson's disease 3. Genetics of Wilson's disease 4. Genetic and environmental modifiers of Wilson's disease 5. Pathogenesis of Wilson's disease 6. Animal models of Wilson's disease 7. Wilson's disease - liver pathology 8. Wilson's disease - brain pathology 9. Hepatic features of Wilson's disease 10. Neurological features 11. Psychopathology 12. Wilson's disease in children 13. Other organs involvement and clinical aspects of Wilson's disease 14. Diagnosis 15. Wilson's disease: anti-copper therapy presently used 16. Liver transplantation in Wilson's disease 17. Wilson's disease - symptomatic liver therapy 18. Wilson's disease: symptomatic neurological therapy 19. Novel perspectives on Wilson's disease treatment 20. Genetic counselling 21. Patient support groups in the management of Wilson's disease
- ISBN: 978-0-444-63625-6
- Editorial: Elsevier
- Encuadernacion: Cartoné
- Páginas: 600
- Fecha Publicación: 01/03/2017
- Nº Volúmenes: 1
- Idioma: Inglés