Homeostasis involves a delicate interplay between generative and degenerativeprocesses to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedbackmechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesizethat key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes Several new concepts wereshared that will stimulate future research and perhaps contribute to better therapies for cancer patients as well as those struggling with the ravages of neurodegeneration.
- ISBN: 978-3-642-16601-3
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 170
- Fecha Publicación: 01/12/2010
- Nº Volúmenes: 1
- Idioma: Inglés