The aim of this book is to reveal to a large spectrum of audience including biologists and physicians the extent of the microRNAs revolution in the cancer society. Alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancer: cancer initiation and progression can involve microRNAs (miRNAs) - small non-coding RNAs that can regulate gene expression. At the present time, the main mechanism of microRNAs alteration in cancer cells seems to be represented by aberrant gene expression, characterized by abnormal levels of expression for mature and/or precursor miRNA sequences in comparison with the corresponding normal tissues. Loss or amplification of miRNA genes has been reported in a variety of cancers and altered patterns of miRNA expression may affect cell cycle and survival programs. Germline and somaticmutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may alsocontribute to cancer predisposition and progression. INDICE: Part 1. Basic Concepts Of Micro-RNA Involvement In Human Cancers. 1. A MicroRNA Primer. 2. MicroRNAs And Cancer - An Overwiew. 3. MicroRNAs As Tumor Suppressors. 4. MicroRNAs As Oncogenes. 5. Mechanisms Of MicroRNA Disregulation In Human Cancers. 6. MicroRNA Quantification In Human Cancers. 7. Mice Models For MicroRNA Involment In Human Cancers. 8. Targets Of Cancer Specific MicroRNAs. 9. Ultraconserved Genes And MicroRNAs: The Cancer Connnection. 10. Therapeutic Implications Of MicroRNAas Involvement In Human Cancers. Part 2. MicroRNAs Involvement In Specific Cancers. 11. MicroRNAs In Lung Cancers. 12. MicroRNAs In Breast Cancer. 13. MicroRNAs In Colon Cancers. 14. MicroRNAs In Thyroid Cancers. 15. MicroRNAs In Neurological Cancers. 16. MicroRNAs In Pancreatic Cancers. 17. MicroRNAs In Lymphomas. 18. MicroRNAs In Leukemias.
- ISBN: 978-1-60327-268-1
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 270
- Fecha Publicación: 01/12/2008
- Nº Volúmenes: 1
- Idioma: Inglés