Diagnostic Pathology: Kidney Diseases

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of common and rare nonneoplastic renal diseases, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Kidney Diseases, fourth edition, is a visually stunning, one-stop resource for every practicing pathologist, nephrologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. INDICE: SECTION 1: INTRODUCTION AND OVERVIEW 4 Introduction to Renal Pathology Robert B. Colvin, MD 24 Normal Kidney Structure Neeraja Kambham, MD and Anthony Chang, MD 36 Normal Kidney Development Sanjay Jain, MD, PhD and Yasar Caliskan, MD 46 Kidney Biopsy Evaluation and Reports Lynn D. Cornell, MD, Surya V. Seshan, MD, and Anthony Chang, MD 50 Harmonized Nephropathy Terminology Mark Haas, MD 54 Common Artifacts and Pitfalls Lynn D. Cornell, MD SECTION 2: GLOMERULAR DISEASES PODOCYTOPATHIES 60 Minimal Change Disease A. Brad Farris, III, MD and Astrid Weins, MD, PhD 68 Classification of Focal Segmental Glomerulosclerosis A. Brad Farris, III, MD and Astrid Weins, MD, PhD 72 Etiologic Classification of Focal Segmental Glomerulosclerosis Robert B. Colvin, MD 74 Focal Segmental Glomerulosclerosis, Primary A. Brad Farris, III, MD and Astrid Weins, MD, PhD 82 Focal Segmental Glomerulosclerosis, Adaptive (Secondary) A. Brad Farris, III, MD and Astrid Weins, MD, PhD 88 Collapsing Glomerulopathy A. Brad Farris, III, MD and Astrid Weins, MD, PhD MEMBRANOUS NEPHROPATHY AND VARIANTS 98 Introduction to Membranous Nephropathy Robert B. Colvin, MD 108 Etiologies of Membranous Glomerulonephritis_Table Robert B. Colvin, MD 110 Introduction to Membranous Nephropathy Anthony Chang, MD 116 Mebranous Nephropathy Due to PLA2R Autoantibodies Anthony Chang, MD and Sanjeev Sethi, MD 120 Membranous Nephropathy Due to non-PLA2R Antibodies Anthony Chang, MD and Sanjeev Sethi, MD 124 Membranous Nephropathy Associated With Systemic Disease Anthony Chang, MD 128 Membranous Nephropathy With Organized Deposits Anthony Chang, MD 132 Membranous Nephropathy With Anti-TBM Antibodies Robert B. Colvin, MD 134 Podocyte Infolding Glomerulopathy Shane Meehan, MB, BCh IGA-RELATED GLOMERULONEPHRITIS 136 Overview of IgA-Related Glomerular Diseases Shane Meehan, MB, BCh 140 IgA Nephropathy Lynn D. Cornell, MD, Robert B. Colvin, MD, and Ian Roberts, MBChB, FRCPath 154 IgA Vasculitis (Henoch-Schönlein Purpura) Anthony Chang, MD and Ian Roberts, MBChB, FRCPath 160 IgA Acute Glomerulonephritis Associated With Staphylococcus aureus Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath 164 Hepatic Disease With IgA Deposition Robert B. Colvin, MD SLE AND RELATED AUTOANTIBODYMEDIATED DISEASES 166 Systemic Lupus Erythematosus Shane Meehan, MB, BCh, Robert B. Colvin, MD, and Ingeborg Bajema, MD 184 Mixed Connective Tissue Disease A. Brad Farris, III, MD 186 Idiopathic Nonlupus Full-House Nephropathy Ingeborg Bajema, MD and Emilie Rijnink, MD, PhD 188 Mixed Cryoglobulinemic Glomerulonephritis A. Brad Farris, III, MD and Charles Alpers, MD ANTI-GBM DISEASES 194 Anti-GBM Glomerulonephritis Anthony Chang, MD 202 Atypical Anti-GBM Disease Lynn D. Cornell, MD COMPLEMENT-RELATED GLOMERULONEPHRITIS 206 Classification of MPGN and Complement-Related Diseases Robert B. Colvin, Md 210 Dense Deposit Disease A. Brad Farris, III, MD 216 C3 Glomerulonephritis Lynn D. Cornell, MD 222 C1q Nephropathy Neeraja Kambham, MD 228 C4 Glomerulopathy Sanjeev Sethi, MD 232 MPGN With Immune Complexes A. Brad Farris, III, MD, Jean Hou, MD, and Mark Haas, MD MONOCLONAL IMMUNOGLOBULIN DISEASES OF GLOMERULI 240 Introduction to Diseases With Monoclonal Immunoglobulin Deposits Robert B. Colvin, MD 244 Monoclonal Immunoglobulin Deposition Disease Lynn D. Cornell, MD 252 Proliferative Glomerulonephritis With Monoclonal IgG Deposits Lynn D. Cornell, MD 256 Membranous Glomerulonephritis With Masked IgG ? Deposits Christopher P. Larsen, MD and Tiffany Caza, MD 260 Type I Cryoglobulinemic Glomerulonephritis Robert B. Colvin, MD and Evan Farkash, MD, PhD 264 Waldenström Macroglobulinemia Anthony Chang, MD 266 Crystalglobulin Glomerulonephritis Anthony Chang, MD and Mariam Priya Alexander, MD AMYLOIDOSIS 270 Amyloidosis Classification A. Brad Farris, III, MD and Sanjeev Sethi, MD 276 AL/AH Amyloidosis A. Brad Farris, III, MD and Sanjeev Sethi, MD 282 AA Amyloidosis A. Brad Farris, III, MD and Sanjeev Sethi, MD 286 AFib Amyloidosis A. Brad Farris, III, MD and Sanjeev Sethi, MD 288 AGel Amyloidosis Sanjeev Sethi, MD 290 ALECT2 Amyloidosis Christopher P. Larsen, MD, Sanjeev Sethi, MD, and Tiffany Caza, MD 292 AApoAI Amyloidosis A. Brad Farris, III, MD and Sanjeev Sethi, MD 293 AApoAII Amyloidosis Robert B. Colvin, MD and Sanjeev Sethi, MD 294 AApoAIV Amyloidosis Sanjeev Sethi, MD 295 AApoCII Amyloidosis Sanjeev Sethi, MD 296 ATTR Amyloidosis A. Brad Farris, III, MD and Sanjeev Sethi, MD IDIOPATHIC FIBRILLARY GLOMERULOPATHIES 298 Diseases With Organized Deposits Robert B. Colvin, MD 302 Fibrillary Glomerulopathy Anthony Chang, MD 308 Immunotactoid Glomerulopathy Anthony Chang, MD and Charles Alpers, MD 312 Fibronectin Glomerulopathy Neeraja Kambham, MD DIABETIC AND RELATED RENAL DISEASE 316 Diabetic Nephropathy Neeraja Kambham, MD and Ian Roberts, MBChB, FRCPath 326 Metabolic Syndrome/Obesity-Related Glomerular Disease Shane Meehan, MB, BCh 330 Idiopathic Nodular Glomerulopathy A. Brad Farris, III, MD and Ian Roberts, MBChB, FRCPath INFECTION-RELATED GLOMERULAR DISEASE 334 Overview of Infection-Related Glomerular Disease Shane Meehan, MB, BCh 338 Acute Poststreptococcal Glomerulonephritis A. Brad Farris, III, MD 346 Postinfectious Glomerulonephritis, Nonstreptococcal A. Brad Farris, III, MD 352 Glomerulonephritis of Chronic Infection, Including Shunt Nephritis A. Brad Farris, III, MD 354 Endocarditis A. Brad Farris, III, MD and Christie L. Boils, MD 358 Syphilis Shane Meehan, MB, BCh 360 Lyme Disease Neeraja Kambham, MD 362 COVID-19 Nephropathies Lynn D. Cornell, MD, Mariam Priya Alexander, MD, and Robert B. Colvin, MD 366 Hepatitis B Virus Anthony Chang, MD 370 Hepatitis C Virus Anthony Chang, MD and Charles Alpers, MD 376 Hepatitis B Virus Anthony Chang, MD 380 HIV-Associated Nephropathy A. Brad Farris, III, MD 386 Miscellaneous HIV-Associated Renal Diseases A. Brad Farris, III, MD 392 Schistosomiasis Neeraja Kambham, MD 394 Filariasis Christie L. Boils, MD and Tiffany Caza, MD 395 Leishmaniasis Kerstin Amann, MD and Robert B. Colvin, MD DRUG-INDUCED GLOMERULAR DISEASES 396 Drug-Induced Minimal Change Disease Anthony Chang, MD and Astrid Weins, MD, PhD 398 Bisphosphonate-Induced Collapsing Glomerulopathy A. Brad Farris, III, MD and Astrid Weins, MD, PhD 399 Chloroquine Toxicity Shane Meehan, MB, BCh 400 Antihepatitis C Virus Drugs Ivy A. Rosales, MD 404 Anti-EGFR Drugs Kammi J. Henriksen, MD GENETIC DISEASES OF GLOMERULUS 406 Overview and Classification of Genetic Diseases of Glomerulus Sanjay Jain, MD, PhD and Yasar Caliskan, MD 408 Genetic Causes of Nephrotic Syndrome Joseph P. Gaut, MD, PhD GENETIC DISEASES OF GLOMERULAR BASEMENT MEMBRANE COLLAGEN 412 Alport Syndrome Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Robert B. Colvin, MD 424 Thin Basement Membrane Disease Joseph P. Gaut, MD, PhD and Helen Liapis, MD GENETIC DISEASES OF PODOCYTE 426 Diffuse Mesangial Sclerosis Joseph P. Gaut, MD, PhD and Helen Liapis, MD 430 Congenital Nephrotic Syndrome of Finnish Type Joseph P. Gaut, MD, PhD and Helen Liapis, MD 434 Pierson Syndrome Joseph P. Gaut, MD, PhD and Helen Liapis, MD 436 Galloway-Mowat Syndrome Stephen M. Bonsib, MD 438 Denys-Drash Syndrome Kammi J. Henriksen, MD and Stephen M. Bonsib, MD 442 Frasier Syndrome Stephen M. Bonsib, MD 446 Podocin Deficiency Joseph P. Gaut, MD, PhD and Helen Liapis, MD 448 a-Actinin-4 Deficiency Joseph P. Gaut, MD, PhD and Helen Liapis, MD 450 Autosomal Dominant FSGS Due To INF2 Mutations Robert B. Colvin, MD 452 APOL1-Related Glomerular Disease Christopher P. Larsen, MD and Tiffany Caza, MD 456 Schimke Immunoosseous Dysplasia Shane Meehan, MB, BCh GENETIC STORAGE AND LIPID DISEASES 458 Fabry Disease Robert B. Colvin, MD and Laura Barisoni, MD 466 Alagille Syndrome Anthony Chang, MD 468 Lecithin Cholesterol Acyltransferase Deficiency Carrie L. Phillips, MD and Stephen M. Bonsib, MD 472 APOE Lipoprotein Glomerulopathy Joseph P. Gaut, MD, PhD and Helen Liapis, MD 474 Type III Hyperlipoproteinemia Joseph P. Gaut, MD, PhD and Helen Liapis, MD 476 I-Cell Disease (Mucolipidosis II) Stephen M. Bonsib, MD 478 Gaucher Glomerulopathy A. Brad Farris, III, MD OTHER GENETIC DISEASES AFFECTING GLOMERULUS 480 Type III Collagen Glomerulopathy Joseph P. Gaut, MD, PhD, L. Nicholas Cossey, MD, FCAP, and Helen Liapis, MD 484 Nail-Patella Syndrome Joseph P. Gaut, MD, PhD and Helen Liapis, MD 486 Glomerulopathy of Hereditary Multiple Exostoses Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath MISCELLANEOUS GLOMERULAR DISEASES 488 Cryofibrinogenic Glomerulopathy Lynn D. Cornell, MD and Mariam Priya Alexander, MD 492 IgM Nephropathy Neeraja Kambham, MD 494 IgG Nephropathy Anthony Chang, MD 498 Vaccination-Associated Renal Disease Astrid Weins, MD, PhD and Mariam Priya Alexander, MD 502 Nephropathies in Chronic Liver Diesease, Including Hepatic Glomerulosclerosis Robert B. Colvin, MD 506 Renal Disease in Rheumatoid Arthritis Neeraja Kambham, MD 512 Hemophagocytic Glomerulopathy Lynn D. Cornell, MD 516 Coenzyme-Q Nephropathies Laura Barisoni, MD 520 Intravascular Large B-Cell Lymphoma Anthony Chang, MD SECTION 3: VASCULAR DISEASES 524 Overview and Classification of Systemic Vasculitides Surya V. Seshan, MD and Ingeborg Bajema, MD ANCA DISEASES 534 ANCA-Related Glomerulonephritis Surya V. Seshan, MD and Ingeborg Bajema, MD 540 Microscopic Polyangiitis Surya V. Seshan, MD and Ingeborg Bajema, MD 548 Granulomatosis With Polyangiitis Surya V. Seshan, MD and Ingeborg Bajema, MD 558 Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Surya V. Seshan, MD and Ingeborg Bajema, MD 564 Drug-Induced ANCA Vasculitis Surya V. Seshan, MD and Ingeborg Bajema, MD NON-ANCA VASCULITIDES 568 Polyarteritis Nodosa Surya V. Seshan, MD 574 Kawasaki Disease Surya V. Seshan, MD and Yael K Heher, MD 576 Giant Cell Arteritis Surya V. Seshan, MD 580 Takayasu Arteritis Surya V. Seshan, MD 584 Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis) Robert B. Colvin, MD THROMBOTIC MICROANGIOPATHIES 586 Introduction to Thrombotic Microangiopathies Neeraja Kambham, MD and Ivy A. Rosales, MD 592 Hemolytic Uremic Syndrome, Infection Related Neeraja Kambham, MD and Ivy A. Rosales, MD 598 Thrombotic Microangiopathy, Genetic Neeraja Kambham, MD and Ivy A. Rosales, MD 602 Thrombotic Microangiopathy, Autoimmune Neeraja Kambham, MD and Ivy A. Rosales, MD 606 Thrombotic Microangiopathy, Drugs Neeraja Kambham, MD and Ivy A. Rosales, MD 610 Postpartum Hemolytic Uremic Syndrome Neeraja Kambham, MD and Ivy A. Rosales, MD 614 Scleroderma Renal Disease Neeraja Kambham, MD and Ivy A. Rosales, MD 620 Multicentric Castleman Disease Lynn D. Cornell, MD OTHER DISEASES AFFECTING ENDOTHELIUM 622 Preeclampsia, Eclampsia, HELLP Syndrome Anthony Chang, MD 624 Radiation Nephropathy Anthony Chang, MD 626 Sickle Cell Nephropathy Anthony Chang, MD 630 Retinal Vasculopathy and Cerebral Leukodystrophy Robert B. Colvin, MD HYPERTENSIVE RENAL DISEASE 632 Hypertensive Renovascular Disease A. Brad Farris, III, MD 640 Renal Artery Stenosis A. Brad Farris, III, MD 644 Fibromuscular Dysplasia A. Brad Farris, III, MD 650 Neurofibromatosis Kammi J. Henriksen, MD and Stephen M. Bonsib, MD THROMBOTIC AND EMBOLIC DISEASE 654 Renal Vein Thrombosis Anthony Chang, MD and Yael K Heher, MD 656 Renal Artery Thrombosis Anthony Chang, MD 658 Atheromatous Emboli Anthony Chang, MD 660 Hydrophilic Polymer Emboli Kammi J. Henriksen, MD SECTION 4: TUBULOINTERSTITIAL DISEASES 664 Overview and Classification of Tubulointerstitial Diseases Robert B. Colvin, MD 666 Differential Diagnosis of Acute Interstitial Nephritis Lynn D. Cornell, MD 672 Granulomatous Interstitial Nephritis Ivy A. Rosales, MD 676 Guide to Crystal Nephropathies ISCHEMIC INJURY 680 Acute Tubular Injury Shane Meehan, MB, BCh 686 Renal Cortical Necrosis Shane Meehan, MB, BCh 688 Sepsis/Shock Joseph P. Gaut, MD, PhD IMMUNOLOGIC TUBULAR DISEASES 690 IgG4-Related Disease Lynn D. Cornell, MD 700 Sjögren Syndrome Josephine M. Ambruzs, MD, MPH 704 Tubulointerstitial Nephritis With Uveitis A. Brad Farris, III, MD 708 Sarcoidosis Josephine M. Ambruzs, MD, MPH 712 Antibrush Border Autoantibody Tubulointerstitial Nephritis Ivy A. Rosales, MD and Robert B. Colvin, MD 714 Anti-Tubular Basement Membrane Disease Robert B. Colvin, MD 716 Idiopathic Hypocomplementemic Tubulointerstitial Nephritis Lynn D. Cornell, MD 720 Tubulointerstitial Nephritis With IgM(+) Plasma Cells Lynn D. Cornell, MD 722 Giant Cell Tubulitis With TBM Deposits Anthony Chang, MD MONOCLONAL IMMUNOGLOBULIN DISEASES OF TUBULOINTERSTIITIUM 724 Light Chain Cast Nephropathy Anthony Chang, MD and Kammi J. Henriksen, MD 730 Light Chain Proximal Tubulopathy With Crystals Lynn D. Cornell, MD 734 Light Chain Proximal Tubulopathy Without Crystals Christopher P. Larsen, MD and Tiffany Caza, MD 738 Crystal-Storing Histiocytosis Mariam Priya Alexander, MD DRUG-INDUCED TUBULOINTERSTITIAL DISEASES 742 Drug-Induced Acute Interstitial Nephritis Lynn D. Cornell, MD and Robert B. Colvin, MD 748 Drugs That Cause Tubulointerstitial Nephritis Robert B. Colvin, MD and Lynn D. Cornell, MD 750 Checkpoint Inhibitor-Induced Kidney Diseases Ivy A. Rosales, MD 754 Papillary Necrosis Neeraja Kambham, MD 758 Cisplatin Nephrotoxicity Shane Meehan, MB, BCh 760 Osmotic Tubulopathy Shane Meehan, MB, BCh and Evan Farkash, MD, PhD 764 Antiviral Drug Nephrotoxicity Shane Meehan, MB, BCh 770 Acute Phosphate Nephropathy Lynn D. Cornell, MD 772 Lithium-Induced Renal Disease Anthony Chang, MD and Yael K Heher, MD 774 Calcineurin Inhibitor Toxicity Shane Meehan, MB, BCh 780 mTOR Inhibitor Toxicity Lynn D. Cornell, MD 782 Vancomycin-Induced Cast Nephropathy Kammi J. Henriksen, MD 784 Anticoagulant-Related Nephropathy Christopher P. Larsen, MD and Tiffany Caza, MD 786 Illicit Drugs and Opioids Kammi J. Henriksen, MD TOXIC INJRY 788 Myoglobinuria/Rhabdomyolysis/Hemoglobinuria Neeraja Kambham, MD 790 Bile Cast Nephropathy Anthony Chang, MD 792 Lead and Other Heavy Metal Toxins Shane Meehan, MB, BCh 796 Ethylene Glycol Toxicity Shane Meehan, MB, BCh 798 Aristolochic Acid Nephropathy Shane Meehan, MB, BCh 800 Balkan Endemic Nephropathy Shane Meehan, MB, BCh 802 Argyria Robert B. Colvin, MD AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE 804 MUC1-Related Autosomal Dominant Tubulointerstitial Kidney Disease Joseph P. Gaut, MD, PhD and Helen Liapis, MD 806 UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease Shane Meehan, MB, BCh 808 REN-Related Autosomal Dominant Tubulointerstitial Kidney Disease Lynn D. Cornell, MD 810 HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease Robert B. Colvin, MD and Marie Claire Gubler, MD GENETIC CRYSTAL DEPOSITION DISEASES 812 Uric Acid Nephropathy/Gout Shane Meehan, MB, BCh 816 Primary Hyperoxaluria Shane Meehan, MB, BCh 818 2,8-Dihydroxyadeninuria Lynn D. Cornell, MD 820 Cystinosis Joseph P. Gaut, MD, PhD and Helen Liapis, MD GENETIC TRANSPORT DISEASES 822 Bartter Syndrome Shane Meehan, MB, BCh 824 Dent Disease Lynn D. Cornell, MD 826 Oculocerebrorenal Syndrome of Lowe Josephine M. Ambruzs, MD, MPH OTHER GENETIC DISEASES AFFECTING TUBULES 828 Mitochondriopathies Surya V. Seshan, MD and Laura Barisoni, MD 832 Systemic Karyomegaly Robert B. Colvin, MD 834 Methylmalonic Acidemia Lynn D. Cornell, MD and Linda Hasadsri, MD, PhD MISCELLANEOUS TUBULOINTERSTITIAL DISEASES 838 Nephrocalcinosis Lynn D. Cornell, MD 840 Secondary Oxalosis Lynn D. Cornell, MD 842 Chronic Interstitial Nephritis in Agricultural Communities Lynn D. Cornell, MD 844 Extramedullary Hematopoiesis Lynn D. Cornell, MD 848 Mastocytosis R. Neal Smith, MD SECTION 5: INFECTIONS OF KIDNEY BACTERIAL INFECTIONS OF KIDNEY 854 Acute Pyelonephritis Neeraja Kambham, MD 862 Chronic Pyelonephritis Neeraja Kambham, MD 866 Xanthogranulomatous Pyelonephritis Neeraja Kambham, MD and Ivy A. Rosales, MD 870 Malakoplakia Neeraja Kambham, MD 874 Tuberculosis Neeraja Kambham, MD 876 BCG Granulomatous Interstitial Nephritis Neeraja Kambham, MD 878 Leprosy Neeraja Kambham, MD 879 Megalocytic Interstitial Nephritis Neeraja Kambham, MD 880 Nocardiosis Neeraja Kambham, MD 882 Leptospirosis Shane Meehan, MB, BCh 884 Whipple Disease Carrie L. Phillips, MD FUNGAL, RICKETTSIAL, AND PARASITIC INFECTIONS OF KIDNEY 886 Mucormycosis Anthony Chang, MD 888 Candidiasis Anthony Chang, MD 889 Histoplasmosis Anthony Chang, MD 890 Coccidioidomycosis Anthony Chang, MD 891 Blastomycosis Anthony Chang, MD 892 Paracoccidioidomycosis Anthony Chang, MD 893 Aspergillosis Anthony Chang, MD 894 Cryptococcosis Anthony Chang, MD 895 Microsporidiosis Robert B. Colvin, MD 896 Rickettsial Infections Shane Meehan, MB, BCh 898 Toxoplasmosis Neeraja Kambham, MD 900 Hydatidosis Stephen M. Bonsib, MD VIRAL INFECTIONS OF KIDNEY 902 Polyomavirus Nephritis Anthony Chang, MD and Evan Farkash, MD, PhD 910 Cytomegalovirus Infection Anthony Chang, MD and R. Neal Smith, MD 912 Adenovirus Infection Anthony Chang, MD and R. Neal Smith, MD 914 Epstein-Barr Virus Nephritis Anthony Chang, MD and R. Neal Smith, MD 916 Herpes Simplex Acute Nephritis Anthony Chang, MD and R. Neal Smith, MD 918 Hantavirus Nephropathy A. Brad Farris, III, MD SECTION 6: DEVELOPMENTAL DISEASES 922 Overview of Congenital Anomalies of Kidney and Urinary Tract Sanjay Jain, MD, PhD 926 Dysplasia/Hypoplasia/Agenesis Sanjay Jain, MD, PhD 932 Oligomeganephronia Robert B. Colvin, MD and Yael K Heher, MD 934 Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney Sanjay Jain, MD, PhD 938 Ask-Upmark Kidney Lynn D. Cornell, MD 940 Renal Tubular Dysgenesis Stephen M. Bonsib, MD SECTION 7: CYSTIC DISEASES 946 Overview of Cystic Diseases Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Stephen M. Bonsib, MD CILIOPATHIES 952 Autosomal Dominant Polycystic Kidney Disease Anthony Chang, MD, Robert B. Colvin, MD, and Yael K Heher, MD 958 Autosomal Recessive Polycystic Kidney Disease Stephen M. Bonsib, MD 964 Nephronophthisis and Related Ciliopathies Kerstin Amann, MD, Helen Liapis, MD, and Robert B. Colvin, MD OTHER GENETIC CYSTIC DISEASES 970 von Hippel-Lindau Disease Stephen M. Bonsib, MD 976 Tuberous Sclerosis Complex Christie L. Boils, MD 982 Zellweger Syndrome Stephen M. Bonsib, MD MISCELLANEOUS CYSTIC DISEASES 984 Medullary Sponge Kidney Lynn D. Cornell, MD and Aleksandr Vasilyev, MD, PhD 986 Mixed Epithelial and Stromal Tumor Family Stephen M. Bonsib, MD 992 Pediatric Cystic Nephroma Angelica R. Putnam, MD and Carrie L. Phillips, MD 996 Acquired Cystic Disease Stephen M. Bonsib, MD and Aleksandr Vasilyev, MD, PhD 1000 Simple and Miscellaneous Cysts Anthony Chang, MD 1002 Renal Lymphangioma/Lymphangiectasia Stephen M. Bonsib, MD and Aleksandr Vasilyev, MD, PhD SECTION 8: DISEASES OF COLLECTING SYSTEM 1008 Introduction to Impediments to Urine Flow Sanjay Jain, MD, PhD 1012 Reflux Nephropathy Sanjay Jain, MD, PhD 1016 Obstructive Uropathy Sanjay Jain, MD, PhD 1020 Nephrolithiasis Shane Meehan, MB, BCh 1026 Loin Pain Hematuria Syndrome Stephen M. Bonsib, MD and Xin Gu, MD SECTION 9: DISEASES OF RENAL ALLOGRAFT 1030 Pathologic Classification of Renal Allograft Diseases Robert B. Colvin, MD INTRODUCTION 1032 Evaluation of Allograft Kidney Lynn D. Cornell, MD and Evan Farkash, MD, PhD 1038 Evaluation of Donor Kidney Lynn D. Cornell, MD and Evan Farkash, MD, PhD REJECTION 1044 Acute T-Cell-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1056 Chronic T-Cell-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1060 Hyperacute Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1064 Acute Antibody-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1072 Chronic Antibody-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1084 Transcript Analysis of Renal Transplant Biopsies Michael Mengel, MD and R. Neal Smith, MD RECURRENT AND DE NOVO DISEASES 1088 Diseases That Recur in Allografts Anthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD 1094 De Novo Focal Segmental Glomerulosclerosis Anthony Chang, MD and Astrid Weins, MD, PhD 1096 De Novo Membranous Glomerulonephritis Anthony Chang, MD 1100 Anti-GBM Disease in Alport Syndrome Anthony Chang, MD and R. Neal Smith, MD 1102 Engraftment Syndrome/Chimerism Transition Syndrome A. Brad Farris, III, MD 1104 Late Post-Transplant Histology Lynn D. Cornell, MD OTHER ALLOGRAFT DISEASES 1108 Acute Allograft Ischemia A. Brad Farris, III, MD 1112 Size Mismatch Allograft Injury Anthony Chang, MD and Yael K Heher, MD 1114 Urine Leak A. Brad Farris, III, MD 1115 Lymphocele A. Brad Farris, III, MD 1116 Transplant Renal Artery Stenosis A. Brad Farris, III, MD 1118 Tranplant Renal Artery or Vein Thrombosis A. Brad Farris, III, MD 1120 Posttransplant Lymphoproliferative Disease A. Brad Farris, III, MD 1130 BK Polyomavirus Neoplasia Evan Farkash, MD, PhD 1132 Protocol Biopsies Lynn D. Cornell, MD and Evan Farkash, MD, PhD 1136 Accommodation Lynn D. Cornell, MD 1138 Tolerance Robert B. Colvin, MD 1142 Kidney Xenografts Ivy A. Rosales, MD KIDNEY PATHOLOGY IN RECIPIENTS OF OTHER TRANSPLANTS 1146 Kidney Diseases in Nonrenal Transplant Recipients Robert B. Colvin, MD 1150 Graft-vs.-Host Glomerulopathies Anthony Chang, MD and Yael K Heher, MD SECTION 10: KIDNEY EXAMINATION 1154 Examination of End-Stage Kidney Shane Meehan, MB, BCh 1160 Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases Kammi J. Henriksen, MD and Stephen M. Bonsib, MD 1164 Evaluation of Transplant Nephrectomy Shane Meehan, MB, BCh and Evan Farkash, MD, PhD 1168 Evaluation of Autopsy Kidneys Kammi J. Henriksen, MD and Mariam Priya Alexander,MD SECTION 11: TECHNIQUES 1174 Kidney Biopsy Reports Surya V. Seshan, MD, Anthony Chang, MD, and Lynn D. Cornell, MD 1176 Needle Biopsy: Evaluation for Adequacy Lynn D. Cornell, MD 1180 Artificial Intelligence and Digital Pathology Analysis of Interstitium Tubules Vessels A. Brad Farris, III, MD 1184 Evaluation of Fibrosis A. Brad Farris, III, MD 1188 Image Analysis of Glomerular Disease Measurement of GBM Thickness and Podocyte Effacement Laura Barisoni, MD 1192 Immunofluorescence on Paraffin Tissue Sections Nidia Messias, MD 1196 EM Processing From Paraffin Tissue A. Brad Farris, III, MD 1198 Detection of Autoantigens in Mebranous Nephropathy Christopher P. Larsen, MD and A. Bernard Collins, BS 1200 Alport Collagen IV Immunofluorescence Robert B. Colvin, MD and A. Bernard Collins, BS 1202 C4d Immunohistochemistry/Immunofluorescence Robert B. Colvin, MD and A. Bernard Collins, BS 1206 Polyomavirus Detection in Tissue Robert B. Colvin, MD 1208 Mass Spectrometry Sanjeev Sethi, MD and Mariam Priya Alexander, MD 1210 Diagnostic Genetics of Kidney Diseases Sanjay Jain, MD, PhD and Yasar Caliskan, MD 1214 Quality Analysis in Renal Pathology Yael K Heher, MD

• ISBN: 978-0-443-10717-7
• Editorial: Elsevier
• Encuadernacion: Cartoné
• Páginas: 1176
• Fecha Publicación: 04/09/2023
• Nº Volúmenes: 1
• Idioma: Inglés