Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease INDICE: Section I: Introduction to Molecular Testing1. Basic Concepts in Molecular Pathology-Introduction to Molecular Testing in Human Disease2. Laboratory Approaches in Molecular Pathology-The Polymerase Chain Reaction3. Next-Generation Sequencing in the Clinical Laboratory4. Automation of the Molecular Diagnostic LaboratorySection II: Molecular Testing in Infectious Disease5. Molecular Testing for Human Imunodeficiency Virus6. Molecular Testing in Hepatitis Virus Related Disease7. Molecular Testing for Human Papillomaviruses8. Molecular Testing for Herpes Viruses9. Molecular Testing for Parvoviruses10. Molecular Testing for Polyomaviruses11. Molecular Testing for Respiratory Viruses12. Molecular Testing for Diseases Associated with Bacterial Infections13. Agents Associated with Sexually Transmitted Infections14. Molecular Methods for Healthcare-Acquired Infections15. Molecular Testing in Emerging Infectious DiseasesSection III: Molecular Testing in Genetic Disease16. Noninvasive Prenatal Screening (NIPS) for Fetal Aneuploidies17. Molecular Testing in Inherited Cardiomyopathies18. Molecular Diagnostics for Coagulopathies19. Molecular Diagnosis of Cystic Fibrosis20. Molecular Testing in HemochromatosisSection IV: Molecular Testing in Oncology21. Molecular Testing in Breast Cancer22. Molecular Pathology of Prostate Cancer23. Molecular Testing in Lung Cancer24. Molecular Testing in Colorectal Cancer25. Molecular Pathology and Testing in Melanocytic Tumors26. Molecular Testing for Glioblastoma27. Molecular Testing in Pancreatic Cancer28. Molecular Testing in Gynecologic Cancer29. The Emerging Genetic Landscape in Renal Cell Carcinoma30. Molecular Testing in Thyroid Cancer31. Molecular Testing in Pediatric CancersSection V: Molecular Testing in Hematopathology32. Molecular Testing in Chronic Myelogenous Leukemia33. Molecular Testing in Acute Myeloid Leukemia34. Molecular Testing in Myeloproliferative Neoplasms35. Molecular Testing in the Assessment of Bone Marrow Transplant EngraftmentSection VI: Molecular Testing in Personalized Medicine36. Personalized Medicine in Cardiovascular Disease37. Personalized Medicine for Coagulopathies38. Personalized Medicine for Hepatitis C Virus39. Personalized Medicine in Cancer TreatmentSection VII: The Future of Molecular Testing40. Imaging Mass Spectrometry in Clinical Pathology41. Whole Genome Sequencing in the Molecular Pathology Laboratory

• ISBN: 978-0-12-822824-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 625
• Fecha Publicación: 01/10/2022
• Nº Volúmenes: 1
• Idioma: Inglés