Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Some of these exercises can be found at the end of each chapter in the form of questions and answers. Readers are also directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions (with addition of time and cost of diagnosis). Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patientExplains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of diseaseFeatures an ancillary website with videos of laboratory tests being performed as well as self-testing exercises where decision trees can be employed to simulate actual clinical decisionsHighlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests INDICE: Section 1: Introduction to Molecular Testing 1. Basic Concepts in Molecular Pathology - Introduction to Molecular Testing in Human Disease 2. Laboratory Approaches in Molecular Pathology - Polymerase Chain Reaction and Other Amplification Techniques 3. Laboratory Approaches in Molecular Pathology - Next Generation Sequencing 4. Laboratory Approaches in Molecular Pathology - Automation in the Molecular Pathology Laboratory Section 2: Molecular Testing in Infectious Disease 5. Molecular Testing for Human Immunodeficiency Virus (HIV) 6. Molecular Testing in Hepatitis Virus-related Disease (HBV, HCV) 7. Molecular Testing for Human Papilloma Viruses 8. Molecular Testing for Herpes Viruses 9. Molecular Testing for Parvoviruses 10. Molecular Testing for Polyomaviruses 11. Molecular Testing for Respiratory Viruses 12. Molecular Testing for Diseases Associated with Bacterial Infection 13. Infectious Agents Associated with Sexually-transmitted Diseases 14. Infectious Agents Associated with Nosocomial Infection (MRSA, C. difficile) 15. Molecular Testing in Emerging Infectious Diseases Section 3: Molecular Testing in Genetic Disease 16. Non-invasive Prenatal Molecular Testing 17. Molecular Testing in Cardiovascular Disease 18. Molecular Testing for Coagulopathies 19. Molecular Testing in Cystic Fibrosis 20. Molecular Testing of Hemochromatosis Section 4: Molecular Testing in Oncology 21. Molecular Testing in Breast Cancer 22. Molecular Testing in Prostate Cancer 23. Molecular Testing in Lung Cancer 24. Molecular Testing in Colorectal Cancer 25. Molecular Testing in Melanoma 26. Molecular Testing for Glioblastoma 27. Molecular Testing in Pancreatic Cancer 28. Molecular Testing in Gynecologic Cancer 29. Molecular Testing in Renal Cancers 30. Molecular Testing in Thyroid Cancers 31. Molecular Testing for Pediatric Cancers Section 5: Molecular Testing in Hematopathology 32. Molecular Testing in Chronic Myelogenous Leukemia 33. Molecular Testing in Acute Myelogenous Leukemia 34. Molecular Testing in Myeloproliferative Neoplasms 35. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment Section 6: Molecular Testing in Personalized Medicine 36. Personalized Medicine in Cardiovascular Disease (CYP2C19) 37. Personalized Medicine for Coagulopathies (CYP2C9, VKORC1) 38. Personalized Medicine for Hepatitis C 39. Personalized Medicine in Cancer Treatment Section 7: The Future of Molecular Testing 40. Mass Spectroscopy in the Molecular Pathology Laboratory 41. Whole-genome Sequencing in the Molecular Pathology Laboratory Case Studies Q&A

• ISBN: 978-0-12-800886-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 450
• Fecha Publicación: 07/10/2016
• Nº Volúmenes: 1
• Idioma: Inglés