Foodomics: Advanced Mass Spectrometry in Modern Food Science and Nutrition

This book introduces the principles of foodomics through the review of advanced Mass Spectrometry (MS) technologies applied to this new discipline. The coverage details specific omics approaches based on MS technologies that have been (or can be) applied in foodomics, providing a picture of the most innovative applications and future trends. It explains the fundamental branches of foodomics such as metabolomics, proteomics, and systems biology. And it provides a global perspective on omics approaches based on MS techniques combined with systems biology in food science and nutrition, a topic not covered so far. INDICE: Preface xiii Contributors xv 1 Foodomics: Principles and Applications 1 Alejandro Cifuentes 1.1 Introduction to Foodomics 1 1.2 Foodomics Applications: Challenges, Advantages, and Drawbacks 6 1.3 Foodomics, Systems Biology, and Future Trends 11 Acknowledgments 12 References 12 2 Next Generation Instruments and Methods for Proteomics 15 Marýa del Carmen Mena and Juan Pablo Albar 2.1 Introduction 15 2.2 Emerging Methods in Proteomics 19 2.3 The Move from Shotgun to Targeted Proteomics Approaches 34 2.4 New Instrumental Methods for Proteomics 40 2.5 Bioinformatics Tools 49 References 55 3 Proteomic–Based Techniques for the Characterization of Food Allergens 69 Gianluca Picariello, Gianfranco Mamone, Francesco Addeo, Chiara Nitride, and Pasquale Ferranti 3.1 Introduction: What is Food Allergy? 69 3.2 Food Allergy: Features and Boundaries of the Disease 70 3.3 Immunopathology of Food Allergy and Role of Proteomics 71 3.4 Identification of Food Allergy Epitopes 73 3.5 Expression Proteomics and Functional Proteomics in Food Allergy 81 3.6 Identification of Allergens in Transformed Products 85 3.7 Concluding Remarks 90 References 91 4 Examination of the Efficacy of Antioxidant Food Supplements Using Advanced Proteomics Methods 101 Ashraf G. Madian, Elsa M. Janle, and Fred E. Regnier 4.1 Introduction 101 4.2 Methods for Studying the Efficacy of Antioxidants 102 4.3 Strategies Used for Proteomic Analysis of Carbonylated Proteins and the Impact of Antioxidants 106 4.4 Studying Oxidation Mechanisms 107 4.5 Quantification of Carbonylation Sites 111 4.6 Biomedical Consequence of Protein Oxidation and the Impact of Antioxidants 112 4.7 Redox Proteomics and Testing the Efficacy of Antioxidants 113 References 117 5 Proteomics in Food Science 125 Jose M. Gallardo, Monica Carrera, and Ignacio Ortea 5.1 Proteomics 125 5.2 Applications in Food Science 132 5.3 Species Identification and Geographic Origin 132 5.4 Detection and Identification of Spoilage and Pathogenic Microorganisms 140 5.5 Changes During Food Storage and Processing and Their Relationship to Quality 144 5.6 Proteomics Data Integration to Explore Food Metabolic Pathways and Physiological Activity of Food Components 149 5.7 Nutriproteomics 150 5.8 Final Considerations and Future Trends 151 References 152 6 Proteomics in Nutritional Systems Biology: Defining Health 167 Martin Kussmann and Laurent Fay 6.1 Introduction 167 6.2 From Food Proteins to Nutriproteomics 171 6.3 Nutritional Peptide and Protein Bioactives 172 6.4 Nutritional Peptide and Protein Biomarkers 174 6.5 Ecosystem–Level Understanding of Nutritional Host Health 178 6.6 Conclusions and Perspectives 181 References 182 7 MS–Based Methodologies for Transgenic Foods Development and Characterization 191 Alberto Valdes and Virginia Garcýa–Canas 7.1 Introduction 191 7.2 Controversial Safety Aspects and Legislation on GMOs 192 7.3 Analysis of GMOs: Targeted Procedures and Profiling Methodologies 193 7.4 Conclusions and Future Outlook 212 Acknowledgments 212 References 212 8 MS–Based Methodologies to Study the Microbial Metabolome 221 Wendy R. Russell and Sylvia H. Duncan 8.1 Introduction 221 8.2 The Gut Microbiota and Their Role in Metabolism 222 8.3 Metagenomics 224 8.4 Metabolomics 225 8.5 Microbial Metabolites in the Human Gut 226 8.6 Analysis of the Microbial Metabolome 229 8.7 Implications for Human Health and Disease 232 8.8 Summary 235 Acknowledgments 235 References 235 9 MS–Based Metabolomics in Nutrition and Health Research 245 Clara Ibanez and Carolina Simó 9.1 Introduction 245 9.2 MS–Based Metabolomics Workflow 246 9.3 Metabolomics in Nutrition–Related Studies 253 9.4 Diet/Nutrition and Disease: Metabolomics Applications 259 9.5 Other Applications in Nutritional Metabolomics 261 9.6 Integration with Other “Omics” 262 9.7 Concluding Remarks 263 Acknowledgments 264 References 264 10 Shaping the Future of Personalized Nutrition with Metabolomics 271 Max Scherer, Alastair Ross, Sofia Moco, Sebastiano Collino, François–Pierre Martin, Jean–Philippe Godin, Peter Kastenmayer, and Serge Rezzi 10.1 Introduction 271 10.2 Metabolomics Technologies 272 10.3 Personalized Nutrition 278 10.4 Conclusion 291 References 292 11 How Does Foodomics Impact Optimal Nutrition? 303 Anna Arola–Arnal, Josep M. del Bas, Antoni Caimari, Anna Crescenti, Francesc Puiggros, Manuel Suarez, and Lluýs Arola 11.1 Introduction 303 11.2 Nutrigenomics 310 11.3 Nutrigenetics and Personalized Nutrition 323 11.4 The Added Value of Foodomics for the Food Industry 329 11.5 Concluding Remarks 337 References 337 12 Lipidomics 351 Isabel Bondia–Pons and Tuulia Hyotylainen 12.1 Definition and Analytical Challenges in Lipidomics 351 12.2 Lipidomics in Nutrition and Health Research 360 12.3 Lipidomics and Food Science 368 12.4 Future Perspectives 371 References 372 13 Foodomics Study of Micronutrients: The Case of Folates 381 Susan J. Duthie 13.1 Folates in the Diet 381 13.2 Folate and Human Health 383 13.3 Measuring Folates in Human Biomonitoring 385 13.4 Folate and Colon Cancer: Establishing Mechanisms of Genomic Instability Using a Combined Proteomic and Functional Approach 387 13.5 Folate Deficiency and Abnormal DNA Methylation: A Common Mechanism Linking Cancer and Atherosclerosis 394 13.6 Summary 397 Acknowledgments 399 References 399 14 Metabolomics Markers in Acute and Endurance/Resistance Physical Activity: Effect of the Diet 405 Sonia Medina, Debora Villano, Jose Ignacio Gil, Cristina Garcýa–Viguera, Federico Ferreres, and Angel Gil–Izquierdo 14.1 Introduction 405 14.2 Metabolomics Consequences of Physical Activity: Metabolites and Physiological Pathways Affected 407 14.3 Metabolomics and Physical Activity: Effect of the Diet 410 14.4 Concluding Remarks and Future Perspectives 411 Acknowledgments 412 References 412 15 MS–Based Omics Evaluation of Phenolic Compounds as Functional Ingredients 415 Debora Villano, Sonia Medina, Jose Ignacio Gil, Cristina Garcýa–Viguera, Federico Ferreres, Francisco A. Tomas–Barberan, and Angel Gil–Izquierdo 15.1 Introduction 415 15.2 Use of Metabolomics in Nutritional Trials 416 15.3 Statistic Tools in Nutritional Metabolomics 421 15.4 Metabolomics from Clinical Trials after Intake of Polyphenol–Rich Foods 421 15.5 Human Metabolome in Low and Normal Polyphenol Dietary Intake 424 15.6 Concluding Remarks and Future Perspectives 424 Acknowledgments 425 References 425 16 Metabolomics of Diet–Related Diseases 429 Marcela A. Erazo, Antonia Garcýa, Francisco J. Ruperez, and Coral Barbas 16.1 Introduction 429 16.2 Analysis of the Metabolome: Metabolomics 431 16.3 Diet–Related Diseases 432 References 446 17 MS–Based Metabolomics Approaches for Food Safety, Quality, and Traceability 453 Marýa Castro–Puyana, Jose A. Mendiola, Elena Ibanez, and Miguel Herrero 17.1 Introduction 453 17.2 MS–Based Metabolomics for Food Safety 455 17.3 MS–Based Metabolomics to Assess Food Quality 462 17.4 MS–Based Metabolomics Strategies for Food Traceability 464 17.5 Conclusions and Future Outlook 467 Acknowledgments 468 References 468 18 Green Foodomics 471 Jose A. Mendiola, Marýa Castro–Puyana, Miguel Herrero, and Elena Ibanez 18.1 Basic Concepts of Foodomics (and How to Make it Greener) 471 18.2 Basic Concepts of Green Chemistry 472 18.3 Green Processes to Produce Functional Food Ingredients 476 18.4 Development of Green Analytical Processes for Foodomics 482 18.5 Comparative LCA Study of Green Analytical Techniques: Case Study 493 18.6 Conclusion 497 Acknowledgments 498 References 498 19 Chemometrics, Mass Spectrometry, and Foodomics 507 Thomas Skov and Søren B. Engelsen 19.1 Foodomics Studies 507 19.2 XC–MS Data 511 19.3 Data Structures and Models 517 19.4 Conclusion 534 References 535 20 Systems Biology in Food and Nutrition Research 539 Matej Oresic 20.1 Systems Biology—New Opportunity for Food and Nutrition Research 539 20.2 Systems Approach to Identify Molecular Networks Behind Health and Disease 542 20.3 Food Metabolome and its Effect on Host Physiology 544 20.4 Building A Systems Biology Platform for Food and Nutrition Research 545 20.5 Future Perspectives 546 References 547 Index 551

• ISBN: 978-1-118-16945-2
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 580
• Fecha Publicación: 26/04/2013
• Nº Volúmenes: 1
• Idioma: Inglés