Gene therapy for autoimmune and inflammatory diseases

This book addresses the latest advances in viral and non-viral vectors, noveltargets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. Thefirst section of the book deals with current research approaches for treatingrheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. Allchapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy. INDICE: From the contents: Rheumatoid arthritis.- Crohn's disease/IBD.- Diabetes.- Cystic fibrosis.- Multiple sclerosis.- Myositis.- Osteoarthritis.- Sjögrens syndrome.- Lupus.- New developments in vectors:Regulated promoters.- AAV Vectors.- Plasmid delivery.- Gutted adenovirus.- Cells as carriers of gene therapy including stem cells.- Perspectives for the future developments of genetherapy for autoimmune and inflammatory therapy.

• ISBN: 978-3-0346-0164-1
• Editorial: Birkhaüser
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 01/06/2010
• Nº Volúmenes: 1
• Idioma: Inglés