Validamycin and its Derivatives: Discovery, Chemical Synthesis, and Biological Activity

Exhibiting interesting chemical activity and structural adaptability, Validamycin, best known as an important agricultural antibiotic, is coming under increasing focus as a source of novel leads for the discovery and development of new drugs. Validamycin and its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents a complete review of the underlying chemistry, synthesis, behaviour and application of these compounds for the first time. Beginning with an introduction to Validamycin, the book goes on to outline the key elements of its discovery and production, including details of its structures, isolation, analysis and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of Validamycin and its intermediates, including Valienamine, Validamine, Valiolamine and Validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with discussion of the economic aspects of working with Validamycin, and potential future applications and trends.With its detailed chemical coverage from a team of expert authors Validamycin and its Derivatives is not only a detailed guide to these compounds themselves, but also to the large-scale industrial production of antibiotics and the adaptation of bioactive agents from agricultural to novel pharmaceutical applications. Offers complete coverage of Validamycin chemistry from  a highly experience team of authors, designed to encourage the discovery of further novel drugs based on Validamycin derivatives Presents an interesting model for establishing new pharmaceutical leads from agricultural sourcesIncludes coverage of the total chemical synthesis of Validamycin and its intermediates, including Valienamine, Validamine, Valiolamine and Validoxylamines INDICE: 1. Introduction 2. Discovery and Production of Validamycin 3. Biological Activities and applications of Validamycin 4. Biosynthesis of Validamycin and Genes Involved in the Biosynthesis 5. Chemical Synthesis of Validamycin and Its Intermediates 6. Preparation of Validamycin Derivatives and Their Biological Activities 7. Economy and Prospects

• ISBN: 978-0-08-100999-4
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 260
• Fecha Publicación: 01/04/2017
• Nº Volúmenes: 1
• Idioma: Inglés