Apoptosis in carcinogenesis and chemotherapy: apoptosis in cancer

The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Comprehensive review of recent development in apoptosis in major cancers and their chemotherapy Translations of laboratory cancer research into emerging anti-cancer strategies INDICE: From the contents 1. Apoptotic Signaling Pathway and Resistance toApoptosis in Breast Cancer Stem Cells. 2. Anti-cancer strategy of transitional cell carcinoma of bladder based on induction of different types of programmed cell deaths. 3. Apoptosis in Carcinogenesis and Chemotherapy of the Uterine Cervix. 4. Apoptosis in Colorectal Tumorigenesis and Chemotherapy. 5. Apoptosis In Cutaneous Melanoma. 6. Apoptosis in Carcinogenesis and Chemotherapy - Esophageal Cancer. 7. Molecular Targets in Gastric Cancer and Apoptosis. 8. Apoptosis and the Tumor Microenvironment in Hematologic Malignancies. 9. Hepatocellular carcinoma. 10. Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin. 11. Cyclooxygenase-2 and its metabolites: implications for lung cancer therapy. 12. Roles of negative and positive growth regulators in nasopharyngeal carcinoma.

• ISBN: 978-1-4020-9596-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 378
• Fecha Publicación: 01/04/2009
• Nº Volúmenes: 1
• Idioma: Inglés