This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways. Identifies various signaling molecules like GRB2 growth factors, A1B1, STAT, TGF?. Provides a critical assessment of surrogate markers involved in the emergence and progression of cancer. Covers the basic principle that drive oncogenesis and pharmacological interventions that lead to therapies. INDICE: Acknowledgement. GRB2 Signaling as a Molecular Target for Cancer. Human arylamine N-acetyltransferase 1 : from drug metabolism to drug target. Targeting Argininosuccinate Synthetase in Cancer Therapy. Parathyroid hormone-related peptide signaling in cancer. Signaling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma. Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract. AIB1: A Transcriptional Coactivator which Integrates Signaling Crosstalk in Cancer Cells. Rational Design of DNA Anti-cancer Agent that Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy. Estrogen Receptor Signaling in Lung Cancer. Microparticle Dissemination of Biological Activities: Implications for Cancer Biology. Protein Kinase D Signaling in Cancer. Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer,Reactive Oxygen Species and Antioxidants. PPARg, Thiazolidinediones, Lung Cancer. Targeting Signal Transducer and Activator of Transcription (STAT) for Anti-Cancer Therapy. Index . . . . . . . .
- ISBN: 978-1-4614-0729-4
- Editorial: Springer New York
- Encuadernacion: Cartoné
- Páginas: 291
- Fecha Publicación: 28/11/2011
- Nº Volúmenes: 1
- Idioma: Inglés