Biomolecular sequence comparison is the origin of bioinformatics. This book gives a complete in-depth treatment of the study of sequence comparison. A comprehensive introduction is followed by a focus on alignment algorithms and techniques, proceeded by a discussion of the theory. The book examines alignment methods and techniques, features a new issue of sequence comparison - the spaced seed technique, addresses several new flexible strategies for coping with various scoring schemes, and covers the theory on the significance of high-scoring segment pairs between two unalignment sequences. Useful appendices on basicconcepts in molecular biology, primer in statistics and software for sequencealignment are included in this reader-friendly text, as well as chapter-ending exercise and research questions. Presents a complete treatment in the state of the art on the study of sequence comparison Covers the spaced seed technique, a new issue of sequence comparison Addresses new flexible strategies for coping with various scoring schemes Features a comprehensive introduction, whichprovides a general tutorial for all level readers INDICE: Introduction.- Part I: Algorithms and Techniques.- Basic Algorithmic Techniques.- Pairwise Sequence Alignment.- Homology Search Tools.- MultipleSequence Alignment.- Part II: Theory.- Anatomy of Spaced Seeds.- Local Alignment Statistics.- Scoring Matrices.- A: Basic Concepts in Molecular Biology.- B: Elementary Probability Theory.- C: Software Packages for Sequence Alignment.- Index.
- ISBN: 978-1-84800-319-4
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 230
- Fecha Publicación: 01/11/2008
- Nº Volúmenes: 1
- Idioma: Inglés