Sphingolipids as signaling and regulatory molecules

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases. Includes a series of mouse animal models currently available for studying the role ofsphingolipids in embryonic development, aging and a series of pathological processes Represents a comprehensive review of the current knowledge of sphingolipid signaling and that research scientists can use it as a reference for their studies Studies of sphingolipids in different system models INDICE: An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown.- Sphingolipid Transport.- Sphingolipid Analysis by High Performance Liquid Chromatography?Ta ndem Mas Spectrometry (HPLC?MS/MS).- Ceramide Synthases: Roles in Cell Physiology and Signaling.- Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family.- Ceramide in Stress Response.- Animal Models for Studying the Pathophysiology of Ceramide.- Ceramide 1?Phosphate in Cell Survival and Inflamatory Signaling.- Ceramide?1?Phosphate in Phagocytosis and CalciumHomeostasis.- Extracellular and Intracellular Actions of Sphingosine?1?Phosphate.- Glucosylceramide in Humans.- Gangliosides as Regulators of Cell MembraneOrganization and Functions.- Cancer Treatment Strategies Targeting Sphingolipid Metabolism.- Therapeutic Strategies for Diabetes and Complications: A Role for Sphingolipids?.- Roles for Sphingolipids in Saccharomyces cerevisiae.- Sphingolipid Signaling in Fungal Pathogens.- Sphingolipids in Parasitic Protozoa.- Biosynthesis of Sphingolipids in Plants (and Some of Their Functions).- Computational Analysis of Sphingolipid Pathway Systems.- Appendix: Introduction toTools and Techniques for Ceramide?Centered Research

• ISBN: 978-1-4419-6740-4
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 287
• Fecha Publicación: 24/08/2010
• Nº Volúmenes: 1
• Idioma: Inglés