Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapiesFeatures contributions by leading experts in the field INDICE: SECTION I: Genetic and Epigenetic effect on cancer through noncoding RNA 1. miRNA and Cancer 2. miRNA biogenesis disruption and cancer 3. Genetic alteration of miRNA affecting cancer pathways 4. The Epigenetic Control of MicroRNA Expression and Cancer 5. Effects of miRNAs on epigenetic machinery 6. Histone modifiers of deregulated miRNAs in cancer 7. miRNA genes epigenetically regulated by DNA methylation in cancer 8. Circulating miRNA increasing the risk of cancer 9. lncRNA as cancer biomarker 10. Genetic variation of lncRNA in cancer 11. Implications of lncRNAs in cancer epigenetics 12. Charting DNA methylation of long non-coding RNA in cancer. 13. Competing endogenous RNA and cancer 14. miRNA-lncRNA-ceRNA network in cancer 15. Noncoding function of protein-coding genes: mRNA 3´ UTR as ceRNAs in cancer 16. Long noncoding RNAs and pseudogenes as ceRNA in cancer 17. Epigenetic programming mechanism guided by piRNAs in cancer 18. Epigenetic loss of the PIWI/piRNA machinery in human tumorigenesis 19. tRNA and cancer 20. Dynamic Reprogramming of tRNA Modifications in Cancer 21. Post-transcriptional modifications of tRNA linked to cancer 22. Circular RNA: a novel non-coding RNA in Cancer 23. Other ncRNA and cancer SECTION II: Cancer Epigenetic Mechanism modulated by non-coding RNA 24. Assessing DNA Methylation and Demethylation of noncoding RNA in cancer 25. Noncoding RNAs act as chromatin Scaffold of Histone Modification Complexes in cancer 26. Heterochromatin modulation by noncoding RNA in cancer 27. Noncoding RNAs (ncRNAs) mediate the recruitment of PcG control of gene expression in cancer SECTION III: Therapeutic implications of ncRNA in cancer 28. Non-coding RNA involved in Cancer Stem Cell Therapy 29. Therapeutic strategies based on targeting ncRNAs for selective silencing 30. Clinical Relevance of non-coding RNA in Cancer 31. Non-coding RNAs: Novel Targets in anticancer drug development SECTION V: Bioinformatics' detection of ncRNA in cancer 32. Cancer ncRNA discovery via High Throughput Sequencing 33. Non-coding RNAs as a cause of cancer: evidence from GWAS and reverse genetics 34. A comparative evaluation of emerging tools for cancer ncRNA retrieval 35. Databases: a comprehensive resource of noncoding RNAs
- ISBN: 978-0-12-811022-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 464
- Fecha Publicación: 01/10/2017
- Nº Volúmenes: 1
- Idioma: Inglés