Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2

Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2 covers wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group. The only source where all intracellular and intercellular redox homeostasis, cascades, and mechanisms of wound healing in elderly peopleDeals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging, and aim to target deteriorating cascades,Helps adjust redox-based treatment regimens befitting modern medicine. INDICE: 1. Redox state of aging skin: A double-edged sword in wound healingQian Chen, Alex Sophabmixay, Thomas Albertson, Gabby Ghasb, Anna Terzian, Lloyd Yan, Lindon Young and Robert Barsotti2. Redox signaling in pressure ulcers within older population: Role of the of antioxidants in their prevention and managementCatalina Rojas-Solé, Víctor Pinilla-González, José Lillo-Moya and Ramón Rodrigo3. Redox signaling in intestinal mucosal wound healingPavel Markovic and Jan Homolak4. Gastrointestinal system senility, postsurgical wound healing, and redox signaling pathwaysAnil Orhan and Süleyman Demiryas5. Redox signaling in age-related vascular disease and wound healingTamer Cebe, Fatih Kizilyel and Bülend Ketenci6. Redox signaling in age-related ocular diseases and healingAhmad Kunbaz7. ROS-mediated redox signaling in diabetic wound healingSaeideh Momtaz and Mohammad Abdollahi8. Nanotherapeutic approach for diabetic wound healing: Cross-talk between redox moleculesMuhammad Asim, Saadiya Zia, Haroon Ur Rashid, Abdul Nasir and Fatma Hussain9. Cerium oxide-based redox active antioxidant and anti-inflammatory biomaterial for wound healing applicationsAnkitha Suresh, Meghna Shetty and Bhisham Narayan Singh10. The redox signaling of ozone in wound repair in the elderly. Perspectives for a thorough review about oxygen-ozone adjunct therapy in traumatic and post-surgical woundsSalvatore Chirumbolo, Marianno Franzini, Umberto Tirelli, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Marianna Chierchia and Luigi Valdenassi11. Contemporary redox-related therapeutic approach to burn wounds in the elderlyMehmet Kaan Akgün, Sara Koçi, Mehmet Can Atayik and Ömer Cennet

• ISBN: 978-0-443-34515-9
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 277
• Fecha Publicación: 01/01/2025
• Nº Volúmenes: 1
• Idioma: Inglés