Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function (i.e hypertrophic or dilated cardiomyopathy) or in the form of arrhythmias (i.e. Brugada syndrome, long QT syndrome). However, it is not uncommon that the first sign of the disease may actually be sudden cardiac death, even before the identification of clear clinical abnormalities. In this last decade, with more than 50 new disease-associated genes identified, the possibility of genetic testing has opened a new opportunity to disease diagnosis and prevention. Clinical and genetic research is continuously on-going not only to identify those at risk, but to better define their level or risk still with limited success. Contributions from experts specialized in inherited diseases Diagnosis and prevention of the disease aided by colour illustrations INDICE: Part A: Familial diseases: (The following issues will be explainedin each chapter): Clinical Description of the Disease.- Risk stratification parameters.- Therapeutic approach to the disease.- Genetic basis.- Role of genetics in diagnosis and risk stratification.- Clinical approach to the non-penetrant carrier of the disease.- Approach to the family with no mutation identified.- Approach to children.- Approach to adults beyond the age of normal presentation of the disease.- Prevention (medications to avoid, exercise limitations, etc).- Part B: Non-familial sudden cardiac death.- Part C: Ethical-legal implications in genetic diagnosis, especially insurance and professional implications for individuals who are non-penetrant carriers.
- ISBN: 978-1-84882-926-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 350
- Fecha Publicación: 01/11/2009
- Nº Volúmenes: 1
- Idioma: Inglés