Cushing's syndrome: pathophysiology, diagnosis and treatment

As a reversible cause of obesity, Cushing’s syndrome is increasingly considered in the differential diagnosis of obese patients. This volume will review the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as menstrual irregularity and depression. It will provide all the up to date information on various strategies to establish the diagnosisof Cushing’s syndrome. Additionally, conditions that represent challenges forthe diagnosis, such as renal failure, pediatric age, cyclic hypercortisolism and pregnancy, will be considered. Cushing’s syndrome is caused by a variety of conditions, and its treatment differs according to the etiology. Approaches to the differential diagnosis and specific treatments for each condition will be provided. Chapters that discuss controversies in diagnosis and differentialdiagnosis will provide a nuanced perspective of these areas. INDICE: Physiology and Pathophysiology of the HPA axis.- Etiologies of Cushing´s syndrome.- Pathogenesis of corticotropic tumors.- Pathogenesis of adrenocortical tumors.- Clinical features of Cushing´s syndrome.- Laboratorial diagnosis of Cushing´s Syndrome: Differential diagnosis with pseudo-Cushing´s conditions as obesity, alcoholism and depression.- Laboratorial diagnosis of Cushing´s syndrome: Differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing´s syndrome.- Imaging for the differential diagnosis of Cushing´s syndrome: MRI, CT and isotopic scanning.- Inferior petrosal sampling for the differential diagnosis of ACTH-dependent Cushing´s syndrome.- ACTH-dependent Cushing syndrome: Treatment of Cushing´s disease.- SurgicalTreatment : Directed to the pituitary : Directed to the adrenals : Radiotherapy: Medical Therapy: ACTH-dependent Cushing syndrome : Clinical and diagnosticaspects, and treatment approaches for ectopic Cushing´s syndrome.- Nelson´s syndrome.- ACTH-independent Cushing´s syndrome: Adrenal adenoma and adenocarcinoma.- ACTH-independent Cushing´s syndrome: Bilateral macronodular hyperplasia.- ACTH-independent Cushing´s syndrome: primary pigmented nodular adrenal disease in the context of Carney´s complex.- Glucocorticoid Resistance.- Post-operative replacement and assessment of HPA axis recovery.- Special aspects of Cushing´s syndrome: Pregnancy.- Special aspects of Cushing´s syndrome- Childhood.-Special aspects of Cushing´s syndrome – Cyclic Cushing´s syndrome.

• ISBN: 978-1-60327-448-7
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 350
• Fecha Publicación: 01/07/2010
• Nº Volúmenes: 1
• Idioma: Inglés