The book features current knowledge concerning mechanisms of metastasis, the role of the bone microenvironment in cancer progression, function of inflammatory cytokines in metastasis and osteolysis, the role of osteoblasts, thus offering cellular and molecular findings that affect the search for drugs and leadto translational studies. In addition, it contains chapters on animal models for cancer, the molecular imaging of cancer cells, and bone marrow transplants. There are also chapters on bone pain and current therapeutic approaches to secondary bone cancer (i.e. the use of bisphosphonates, chemotherapy, hormone therapy), of particular relevance to the clinician. With chapters written by authorities in the field, the book is of interest to academic clinicians, researchers of bone and bone cancers, professional staff of hospitals and pharmaceutical houses, and personnel involved in, and concerned with, cancer care and therapy. With chapters written by authorities in the field, the reader will be made aware of the current status of the disease, appropriate treatment and a sense of where future research is likely to lead INDICE: From the contents Primary and Secondary Bone Cancers: A General Overview.- Blood-Bone Axis and Bone Marrow Microenvironment.- Genetics of Osteosarcoma.- Multiple Myeloma and Other Hematological Malignancies of Bone.- Mechanisms of Metastasis to Bone: The Role of Bone Marrow Endothelium.- Lysophosphatidic Acid: Role in Bone and Bone Cancer.- Role of Bone Microenvironment/Metastatic Niche in Cancer Progression.- Detection and Characterization of Disseminated Tumor Cells Present in Bone Marrow of Cancer Patients.- Molecular Imagingof Cancer Cells Growing in Bone.- Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis.- Prostate Cancer Bone Colonization: Osteomimicryin the Bone Niche.- Bone Pain Associated with Cancer Metastasis.- Small Animal Models for the Study of Cancer in Bone.- Hormonal Therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates.- Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents.
- ISBN: 978-1-84882-018-0
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 255
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés