Discovery and Development of Antidiabetic Agents from Natural Products: Natural Product Drug Discovery

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discoveryProvides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issuesPresents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab INDICE: 1. Bioactive Compounds from Plants with Anti-diabetic properties 2. Identification and extraction of anti-diabetic agents from natural sources 3. Identification and extraction of anti-diabetic antioxidants from natural sources 4. Bioactive Compounds from Anti-diabetic Plants of Africa 5. Bioactive Compounds from Anti-diabetic Plants of the Khandesh Region 6. Computer-aided discovery of glycogen phosphorylase inhibitors exploiting natural products 7. Anti-diabetic Natural Saponins 8. Mangiferin: Natural distribution, isolation and synthesis 9. Resveratrol and its synthetic analogues: A survey 10. Alpha-glucosidase enzyme inhibitors from natural products 11. Glucose Transporter 4 (GLUT4) Translocation Activators from Nature 12. Management of Insulin resistance with natural products and their derivatives: Past, present and future prospects 13. Inflammation and diabetes: An update on the therapeutic potency of natural products

• ISBN: 978-0-12-809450-1
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 332
• Fecha Publicación: 08/11/2016
• Nº Volúmenes: 1
• Idioma: Inglés